Inefficient processing of mRNA for the membraneform of IgE is a genetic mechanism to limit recruitment of IgE‐secreting cells

• Published in: European Journal of Immunology Vol. 36; no. 7; pp. 1917 - 1925
• Main Authors: Karnowski, Alexander, Achatz‐Straussberger, Gertrude, Klockenbusch, Cordula, Achatz, Gernot, Lamers, Marinus C.
• Format: Journal Article
• Language: English
• Published: Weinheim WILEY‐VCH Verlag 01.07.2006
• Subjects: Allergy; B cell; Class switch; Immune response; Polyadenylation

Immunoglobulin E (IgE) is the key effector element in allergic diseases ranging from innocuous hay fever to life‐threatening anaphylactic shock. Compared to other Ig classes, IgE serum levels are very low. In its membrane‐bound form (mIgE), IgE behaves as a classical antigen receptor on B lymphocyte...