Metabolism and Excretion of [14C]Mobocertinib, a Selective Covalent Inhibitor of Epidermal Growth Factor Receptor (EGFR) Exon 20 Insertion Mutations, in Healthy Male Subjects - Chen, Hao; Shah, Abhi; Kato, Suguru; Griffin, Robert; Zhang, Steven; Pusalkar, Sandeepraj; Cohen, Lawrence; Li, Yuexian; Chowdhury, Swapan K.; Zhu, Sean Xiaochun (Drug metabolism and disposition, 2024)
Keywords: absorption, distribution, metabolism, and excretion; accelerator mass spectrometry; ADME; Administration, Oral; Adult; AMS; Aniline Compounds; Carbon Radioisotopes; cDNA-expressed recombinant human cytochrome P450 (Supersomes); CYP; cytochrome P450; EGFR; epidermal growth factor receptor; ErbB Receptors - antagonists & inhibitors; ErbB Receptors - genetics; ErbB Receptors - metabolism; ex20ins; exon 20 insertion; Exons; Feces - chemistry; Healthy Volunteers; high resolution mass spectrometry; high-performance liquid chromatography; HPLC; HRMS; HSA; HSA-Cys; HSA-cysteine conjugate; human serum albumin; Humans; Indoles; liquid scintillation counting; LSC; Male; Middle Aged; MS/MS; Mutagenesis, Insertional; non–small cell lung cancer; NSCLC; Protein Kinase Inhibitors - administration & dosage; Protein Kinase Inhibitors - blood; Protein Kinase Inhibitors - pharmacokinetics; Protein Kinase Inhibitors - pharmacology; Pyrimidines; rhCYP; tandem mass spectrometry; TECRA; total extracted circulating radioactivity; total radioactivity; TRA; UHPLC; ultra-high performance liquid chromatography; Young Adult; TECRA; TRA; NSCLC; ADME; AMS; HSA-Cys; MS/MS; EGFR; ex20ins; HRMS; rhCYP; HSA; CYP; UHPLC; LSC; HPLC