TGF-beta-Mediated Suppression by CD4+CD25+ T Cells Is Facilitated by CTLA-4 Signaling

• Published in: The Journal of immunology (1950) Vol. 177; no. 4; pp. 2331 - 2339
• Main Authors: Oida, Takatoku, Xu, LiLi, Weiner, Howard L, Kitani, Atsushi, Strober, Warren
• Format: Journal Article
• Language: English
• Published: United States Am Assoc Immnol 15.08.2006
• Subjects: Animals; Antigens, CD; Antigens, Differentiation - physiology; Cell Line; CTLA-4 Antigen; Immune Tolerance; Mice; Mice, Inbred A; Signal Transduction - immunology; T-Lymphocytes, Regulatory - immunology; Transforming Growth Factor beta - biosynthesis; Transforming Growth Factor beta - physiology

CD4+CD25+ T cells play a pivotal role in immunological homeostasis by their capacity to exert immunosuppressive activity. However, the mechanism by which these cells function is still a subject for debate. We previously reported that surface (membrane) TGF-β produced by CD4+CD25+ T cells was an effe...