The Early IL-4 Response to Leishmania major and the Resulting Th2 Cell Maturation Steering Progressive Disease in BALB/c Mice Are Subject to the Control of Regulatory CD4+CD25+ T Cells

• Published in: The Journal of immunology (1950) Vol. 169; no. 6; pp. 3232 - 3241
• Main Authors: Aseffa, Abraham, Gumy, Alain, Launois, Pascal, MacDonald, H. Robson, Louis, Jacques A, Tacchini-Cottier, Fabienne
• Format: Journal Article
• Language: English
• Published: United States Am Assoc Immnol 15.09.2002
• Subjects: Adoptive Transfer; Animals; Antibodies, Monoclonal - administration & dosage; CD4-Positive T-Lymphocytes - immunology; CD4-Positive T-Lymphocytes - metabolism; CD4-Positive T-Lymphocytes - pathology; Cell Differentiation - immunology; Disease Progression; Disease Susceptibility - immunology; Female; Interleukin-4 - antagonists & inhibitors; Interleukin-4 - biosynthesis; Interleukin-4 - immunology; Leishmania major - immunology; Leishmaniasis, Cutaneous - immunology; Leishmaniasis, Cutaneous - pathology; Lymphocyte Activation; Lymphocyte Depletion - adverse effects; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, SCID; Receptors, Interleukin-2 - biosynthesis; Spleen - cytology; Spleen - transplantation; T-Lymphocyte Subsets - immunology; T-Lymphocyte Subsets - metabolism; T-Lymphocyte Subsets - pathology; T-Lymphocytes, Regulatory - immunology; Th2 Cells - immunology; Th2 Cells - pathology

Susceptibility and development of Th2 cells in BALB/c mice infected with Leishmania major result from early IL-4 production by Vβ4Vα8 CD4+ T cells in response to the Leishmania homolog of mammalian RACK1 Ag. A role for CD4+CD25+ regulatory T cells in the control of this early IL-4 production was inv...