Low Expression of TLR-1, -2, -4 a IL-2, -2R, -10, -10R and TGFb1 in Pseudosynovial Tissue Collected at Revision Total Knee Arthroplasty for Aseptic Loosening

• Published in: Acta chirurgiae orthopaedicae et traumatologiae Čechoslovaca Vol. 82; no. 1; pp. 67 - 75
• Main Authors: Tománková, T., Kriegová, E., Fillerová, R., Lužná, P., Ehrmann, J., Gallo, J.
• Format: Journal Article
• Language: Czech
• Published: Czech Republic 01.02.2015
• Subjects: Arthroplasty, Replacement, Hip; Arthroplasty, Replacement, Knee; Case-Control Studies; Cytokines - biosynthesis; Cytokines - genetics; Female; Gene Expression - immunology; Hip Prosthesis; Humans; Immunity, Innate; Knee Prosthesis; Male; Prosthesis Failure; Receptors, Cytokine - biosynthesis; Receptors, Cytokine - genetics; Reoperation; RNA, Messenger - genetics; Synovial Membrane - immunology; Toll-Like Receptors - biosynthesis; Toll-Like Receptors - genetics

Aseptic loosening (AL) and periprosthetic osteolysis (PPOL) in total hip (THA) and knee (TKA) arthroplasty are linked to an inflammatory process initiated by wear debris released from artificial joints. There is still limited information about the contribution of Toll-like receptors (TLRs) and disti...