Lp(a) (Lipoprotein(a)) Levels Predict Progression of Carotid Atherosclerosis in Subjects With Atherosclerotic Cardiovascular Disease on Intensive Lipid Therapy: An Analysis of the AIM-HIGH (Atherothrombosis Intervention in Metabolic Syndrome With Low HDL/High Triglycerides: Impact on Global Health Outcomes) Carotid Magnetic Resonance Imaging Substudy—Brief Report

• Published in: Arteriosclerosis, thrombosis, and vascular biology Vol. 38; no. 3; pp. 673 - 678
• Main Authors: Hippe, Daniel S., Phan, Binh P., Sun, Jie, Isquith, Daniel A., O’Brien, Kevin D., Crouse, John R., Anderson, Todd, Huston, John, Marcovina, Santica M., Hatsukami, Thomas S., Yuan, Chun, Zhao, Xue-Qiao
• Format: Journal Article
• Language: English
• Published: United States American Heart Association, Inc 01.03.2018
• Subjects: Adult; Aged; Aged, 80 and over; Biomarkers - blood; Carotid Arteries - diagnostic imaging; Carotid Arteries - drug effects; Carotid Arteries - pathology; Carotid Artery Diseases - blood; Carotid Artery Diseases - diagnostic imaging; Carotid Artery Diseases - drug therapy; Carotid Artery Diseases - pathology; Cholesterol, LDL - blood; Double-Blind Method; Female; Humans; Hypolipidemic Agents - therapeutic use; Lipoprotein(a) - blood; Magnetic Resonance Angiography; Male; Middle Aged; Plaque, Atherosclerotic; Predictive Value of Tests; Risk Factors; Time Factors; Treatment Outcome; atherosclerosis; lipids; risk factors; lipoprotein; lp(a); triglycerides; lipoprotein(a)

OBJECTIVE—To assess whether Lp(a) (lipoprotein(a)) levels and other lipid levels were predictive of progression of atherosclerosis burden as assessed by carotid magnetic resonance imaging in subjects who have been treated with LDL-C (low-density lipoprotein cholesterol)–lowering therapy and particip...