2141. Preclinical Evaluation of PA-001: A Novel, Potential Macrocyclic Peptide-Based Treatment for COVID-19 Which Binds to the S2 Subunit of SARS-CoV-2 Spike Protein

• Published in: Open Forum Infectious Diseases Vol. 10; no. Supplement_2
• Main Authors: Kawamura, Tatsuro, Ohuchi, Masaki, Nagasawa, Takayuki, Ohashi, Hirofumi, Iwata-Yoshikawa, Naoko, Shiwa-Sudo, Nozomi, Sakai, Yusuke, Matsui, Katsuma, Matsumoto, Masatoshi, Kurasaki, Haruaki, Nagatomo, Kazutaka, Ito, Shoko, Kawamura, Naoki, Masuya, Keiichi, Nagata, Noriyo, Watashi, Koichi, Suzuki, Tadaki, Kitamura, Hidetomo, Murakami, Masato
• Format: Journal Article
• Language: English; Japanese
• Published: US Oxford University Press (OUP) 27.11.2023; Oxford University Press
• Subjects: Abstract

Abstract Background Despite the approval of a few COVID-19 drugs, various mutations of SARS-CoV-2 continue to emerge and pose as a threat to the efficacy of COVID-19 treatments. To address the unmet clinical need for broad-spectrum treatments, we identified and performed preclinical evaluation of PA...