Control of Specific Growth Rate in Fed-Batch Bioprocesses: Novel Controller Design for Improved Noise Management

• Published in: Processes Vol. 8; no. 6; p. 679
• Main Authors: Brignoli, Yann, Freeland, Brian, Cunningham, David, Dabros, Michal
• Format: Journal Article
• Language: English
• Published: 01.06.2020

Accurate control of the specific growth rate (µ) of microorganisms is dependent on the ability to quantify the evolution of biomass reliably in real time. Biomass concentration can be monitored online using various tools and methods, but the obtained signal is often very noisy and unstable, leading...