Qualitative and quantitative analysis of the major constituents in Chinese medicinal preparation Guan-Xin-Ning injection by HPLC–DAD–ESI-MSⁿ

• Published in: Journal of pharmaceutical and biomedical analysis Vol. 59; pp. 184 - 189
• Main Authors: Ruan, Ming, Li, Yi, Li, Xin, Luo, Jianguang, Kong, Lingyi
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 05.02.2012; Elsevier
• Subjects: 4-hydroxybenzoic acid; Analysis; Analytical, structural and metabolic biochemistry; Biological and medical sciences; caffeic acid; China; chlorogenic acid; coronary disease; danshensu; ferulic acid; Fundamental and applied biological sciences. Psychology; General pharmacology; high performance liquid chromatography; Ligusticum; Medical sciences; Pharmacology. Drug treatments; quality control; quantitative analysis; rosmarinic acid; Salvia miltiorrhiza; salvianolic acid; vanillin; China; Asia; Chemical analysis; Pharmacognosy; HPLC chromatography; Guan-Xin-Ning injection; Injection; Major constituents; Electrospray; Folk medicine; HPLC-DAD-ESI-MS; Preparation; Quality control; Dosage form; Diode array; Qualitative analysis; Traditional Chinese medicinal preparation; Quantitative analysis

Guan-Xin-Ning (GXN) injection, a traditional Chinese medicinal preparation consisting of Radix Salvia miltiorrhiza and Rhizoma Ligusticum chuanxiong, has been used to treat coronary heart disease and angina pectoris in China for decades. In this paper, a HPLC/DAD/ESI-MSⁿ method was successfully deve...