IL-17 induces autoantibody overproduction and peripheral blood mononuclear cell overexpression of IL-6 in lupus nephritis patients

• Published in: Chinese medical journal Vol. 116; no. 4; pp. 543 - 548
• Main Author: 汪涛 阳晓 杨念生 余学清 董光富 叶任高 史伟 刘双信
• Format: Journal Article
• Language: English
• Published: China Department of Nephrology and Rheumatology, Guangdong Provincial People's Hospital, Guangzhou 510080, China%Department of Nephrology, Key Clinical Kidney Research Institute of Ministry of Health, First Affiliated Hospital, Sun Yat-sen University of Medical Sciences, Guangzhou 510080, China 01.04.2003
• Subjects: Adolescent; Adult; Antibodies, Antinuclear - biosynthesis; Autoantibodies - biosynthesis; Female; Humans; Immunoglobulin G - biosynthesis; Interleukin-17 - pharmacology; Interleukin-6 - biosynthesis; Interleukin-6 - genetics; Leukocytes, Mononuclear - metabolism; Lupus Nephritis - immunology; Male; RNA, Messenger - analysis; 免疫球蛋白G; 外周血单核细胞; 狼疮性肾炎; 白细胞介素-17; 白细胞介素-6; peripheral blood mononuclear cells; IgG; lupus nephritis; IL-6; IL-17; anti-dsDNA

Objective To investigate the role of IL-17 in the overproduction of autoantibodies and IL-6 overexpression by peripheral blood mononuclear cells (PBMC) of lupus nephritis (LN) patients.Methods Fifteen consecutively hospitalized LN patients were selected as subjects and 15 healthy adults as normal co...