The relationship between MTHFR gene polymorphisms,plasma homocysteine levels and diabetic retinopathy in type 2 diabetes mellitus

• Published in: Chinese medical journal Vol. 116; no. 1; pp. 145 - 147
• Main Author: 孙家忠 徐焱成 朱宜莲 鲁红云 邓浩华 范幼筠 孙苏欣 张颖
• Format: Journal Article
• Language: English
• Published: China Department of Endocrinology, Zhongnan Hospital, Wuhan University, Wuhan 430071, China 2003
• Subjects: 2型糖尿病; Aged; Diabetes Mellitus, Type 2 - complications; Diabetic Retinopathy - etiology; Female; Genotype; Homocysteine - blood; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; MTHFR基因多态性; Mutation; Oxidoreductases Acting on CH-NH Group Donors - genetics; Polymorphism, Genetic; 相关性; 糖尿病视网膜病; 血浆高半胱氨酸水平; homocysteine; diabetic retinopathy; methylenetetrahydrofolate reductase gene

Objective To evaluate the role of methylenetetrahydrofolate reductase(MTHFR)gene polymorphisms and plasma homocysteine levels in patients with type 2 diabetes mellitus and diabetic retinopathy(DR).Methods Total of 208 patients with type 2 diabetes mellitus and 57 controls were recruited into the stu...