Experimental study on the mechanism of sex difference in the risk of torsade de pointes

• Published in: Chinese medical journal Vol. 117; no. 4; pp. 538 - 541
• Main Author: 阮燕菲 刘念 周强 李泱 王琳
• Format: Journal Article
• Language: English
• Published: China Department of Cardiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China 01.04.2004
• Subjects: Action Potentials; Animals; Electrocardiography; Female; Male; QT间期; Rabbits; Risk; Sex Characteristics; Sotalol; Torsades de Pointes - etiology; Torsades de Pointes - physiopathology; 危险因素; 室性心动过速; 心电图; 病理机制; sex characteristics; animal experimentation; torsade de pointes; action potentials

Background Torsade de pointes (TdP) is a form of polymorphic ventricular tachycardia featuring prolonged QT intervals. Female gender is associated with an increased risk of TdP. However, the causes of the sex difference in risk are poorly understood. Recently, transmural dispersion of repolarization...