Regulation of α3 Nicotinic Acetylcholine Receptor Subunit mRNA Levels by Nerve Growth Factor and Cyclic AMP in PC12 Cells

• Published in: Journal of neurochemistry Vol. 74; no. 4; pp. 1346 - 1354
• Main Authors: Nakayama, Hitoshi, Ueno, Satoshi, Ikeuchi, Toshihiko, Hatanaka, Hiroshi
• Format: Journal Article
• Language: English
• Published: Oxford UK Blackwell Science Ltd 01.04.2000; Blackwell
• Subjects: Acetylcholine receptor; Biological and medical sciences; Central nervous system; Central neurotransmission. Neuromudulation. Pathways and receptors; Cyclic AMP; Fundamental and applied biological sciences. Psychology; Nerve growth factor; Nicotinic receptor; PC12 cells; Regulation; Vertebrates: nervous system and sense organs; Signal transduction; Cholinergic receptor; Regulation(control); Cell line; Neuron; Cyclic AMP; Nerve growth factor; Gene expression; Subunit; In vitro; Nicotinic receptor

: To investigate the effects of nerve growth factor (NGF) and cyclic AMP (cAMP) on the level of the nicotinic acetylcholine receptor subunit α3 mRNA, we used PC12h cells, PC12 cells expressing dominant‐negative Ras protein, and the parental PC12 cells. PC12h cells have NGF‐responsive tyrosine hydrox...