Combination of diminazene aceturate and resveratrol reduces the toxic effects of chemotherapy in treating Trypanosoma evansi infection

• Published in: Comparative clinical pathology Vol. 25; no. 1; pp. 137 - 144
• Main Authors: Baldissera, Matheus D., Bottari, Nathieli B., Rech, Virginia C., Nishihira, Vivian S. K., Oliveira, Camila B., Cargnin, Lara P., Moresco, Rafael N., Thomé, Gustavo R., Schetinger, Maria Rosa C., Morsch, Vera M., Monteiro, Silvia G., Tonin, Alexandre A., Da Silva, Aleksandro S.
• Format: Journal Article
• Language: English
• Published: London Springer London 2016; Springer Nature B.V
• Subjects: Hematology; Medicine; Medicine & Public Health; Oncology; Original Article; Pathology; Trypanosoma evansi; Diamidine; Oxidative stress; Antioxidant; Inclusion complex; Trypanosomosis

The aim of this study was to evaluate the effects of resveratrol (RSV) in its free or complexed (cyclodextrin) forms in association with diminazene aceturate (DA), as an attempt to reduce the toxic effects of this standard chemotherapy on renal and hepatic samples of mice experimentally infected wit...