Relevance of augmented kisspeptin signaling through H364 KISS1R in central precocious puberty
[Display omitted] •Elevated levels of Kp-10, NKB and NPY in a girl with idiopathic central precocious puberty.•Reduction in the levels of the neuropeptides post GnRHa treatment.•Functional characterization of H364 variant (homozygous) in KISS1R that she harbours.•Increased signaling response post st...
Saved in:
Published in | Gene Vol. 895; p. 148016 |
---|---|
Main Authors | , , , , , , , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Elsevier B.V
15.02.2024
|
Subjects | |
Online Access | Get full text |
Cover
Loading…
Abstract | [Display omitted]
•Elevated levels of Kp-10, NKB and NPY in a girl with idiopathic central precocious puberty.•Reduction in the levels of the neuropeptides post GnRHa treatment.•Functional characterization of H364 variant (homozygous) in KISS1R that she harbours.•Increased signaling response post stimulation of H364 KISS1R with high doses of Kp-10.
Understanding the pathophysiology of idiopathic central precocious puberty (ICPP) is essential, in view of its consequences on reproductive health and metabolic disorders in later life. Towards this, estimation of circulating levels of the neuropeptides, viz; Kisspeptin (Kp-10), Neurokinin B (NKB) and Neuropeptide Y (NPY), acting upstream to Gonadotropin-Releasing Hormone (GnRH), has shown promise. Insights can also be gained from functional studies on genetic variations implicated in ICPP. This study investigated the pathophysiology of ICPP in a girl by exploring the therapeutic relevance of the circulating levels of Kp-10, NKB, NPY and characterizing the nonsynonymous KISS1R variant, L364H, that she harbours, in a homozygous condition. Plasma levels of Kp-10, NKB and NPY before and after GnRH analog (GnRHa) treatment, were determined by ELISA. It was observed that GnRHa treatment resulted in suppression of circulating levels of Kp-10, NKB and NPY. Further, the H364 variant in KISS1R was generated by site directed mutagenesis. Post transient transfection of either L364 or H364 KISS1R variant in CHO cells, receptor expression was ascertained by western blotting, indirect immunofluorescence and flow cytometry. Kp-10 stimulated signalling response was also determined by phospho-ERK and inositol phosphate production. Structure-function studies revealed that, although the receptor expression in H364 KISS1R was comparable to L364 KISS1R, there was an enhanced signalling response through this variant at high doses of Kp-10. Thus, elevated levels of Kp-10, acting through H364 KISS1R, contributed to the manifestation of ICPP, providing further evidence that dysregulation of Kp-10/KISS1R axis impacts the onset of puberty. |
---|---|
AbstractList | Understanding the pathophysiology of idiopathic central precocious puberty (ICPP) is essential, in view of its consequences on reproductive health and metabolic disorders in later life. Towards this, estimation of circulating levels of the neuropeptides, viz; Kisspeptin (Kp-10), Neurokinin B (NKB) and Neuropeptide Y (NPY), acting upstream to Gonadotropin-Releasing Hormone (GnRH), has shown promise. Insights can also be gained from functional studies on genetic variations implicated in ICPP. This study investigated the pathophysiology of ICPP in a girl by exploring the therapeutic relevance of the circulating levels of Kp-10, NKB, NPY and characterizing the nonsynonymous KISS1R variant, L364H, that she harbours, in a homozygous condition. Plasma levels of Kp-10, NKB and NPY before and after GnRH analog (GnRHa) treatment, were determined by ELISA. It was observed that GnRHa treatment resulted in suppression of circulating levels of Kp-10, NKB and NPY. Further, the H364 variant in KISS1R was generated by site directed mutagenesis. Post transient transfection of either L364 or H364 KISS1R variant in CHO cells, receptor expression was ascertained by western blotting, indirect immunofluorescence and flow cytometry. Kp-10 stimulated signalling response was also determined by phospho-ERK and inositol phosphate production. Structure-function studies revealed that, although the receptor expression in H364 KISS1R was comparable to L364 KISS1R, there was an enhanced signalling response through this variant at high doses of Kp-10. Thus, elevated levels of Kp-10, acting through H364 KISS1R, contributed to the manifestation of ICPP, providing further evidence that dysregulation of Kp-10/KISS1R axis impacts the onset of puberty. [Display omitted] •Elevated levels of Kp-10, NKB and NPY in a girl with idiopathic central precocious puberty.•Reduction in the levels of the neuropeptides post GnRHa treatment.•Functional characterization of H364 variant (homozygous) in KISS1R that she harbours.•Increased signaling response post stimulation of H364 KISS1R with high doses of Kp-10. Understanding the pathophysiology of idiopathic central precocious puberty (ICPP) is essential, in view of its consequences on reproductive health and metabolic disorders in later life. Towards this, estimation of circulating levels of the neuropeptides, viz; Kisspeptin (Kp-10), Neurokinin B (NKB) and Neuropeptide Y (NPY), acting upstream to Gonadotropin-Releasing Hormone (GnRH), has shown promise. Insights can also be gained from functional studies on genetic variations implicated in ICPP. This study investigated the pathophysiology of ICPP in a girl by exploring the therapeutic relevance of the circulating levels of Kp-10, NKB, NPY and characterizing the nonsynonymous KISS1R variant, L364H, that she harbours, in a homozygous condition. Plasma levels of Kp-10, NKB and NPY before and after GnRH analog (GnRHa) treatment, were determined by ELISA. It was observed that GnRHa treatment resulted in suppression of circulating levels of Kp-10, NKB and NPY. Further, the H364 variant in KISS1R was generated by site directed mutagenesis. Post transient transfection of either L364 or H364 KISS1R variant in CHO cells, receptor expression was ascertained by western blotting, indirect immunofluorescence and flow cytometry. Kp-10 stimulated signalling response was also determined by phospho-ERK and inositol phosphate production. Structure-function studies revealed that, although the receptor expression in H364 KISS1R was comparable to L364 KISS1R, there was an enhanced signalling response through this variant at high doses of Kp-10. Thus, elevated levels of Kp-10, acting through H364 KISS1R, contributed to the manifestation of ICPP, providing further evidence that dysregulation of Kp-10/KISS1R axis impacts the onset of puberty. |
ArticleNumber | 148016 |
Author | Pande, Shailesh Begum, Shahina Mahale, Smita D. Patil, Anushree Rao, Sudha Tandon, Deepti Pathak, Bhakti R. Bhanarkar, Shital R. Banerjee, Antara A. Surve, Suchitra V. Mehta, Amrita Joshi, Beena Chauhan, Sanjay Keshwani, Rachna Modi, Deepak N. Bombe, Shweta |
Author_xml | – sequence: 1 givenname: Antara A. surname: Banerjee fullname: Banerjee, Antara A. organization: ICMR-National Institute for Research in Reproductive and Child Health, Jehangir Merwanji Street, Parel, Mumbai 400 012, India – sequence: 2 givenname: Shital R. surname: Bhanarkar fullname: Bhanarkar, Shital R. organization: ICMR-National Institute for Research in Reproductive and Child Health, Jehangir Merwanji Street, Parel, Mumbai 400 012, India – sequence: 3 givenname: Rachna surname: Keshwani fullname: Keshwani, Rachna organization: Bai Jerbai Wadia Hospital For Children, Acharya Donde Marg, Parel, Mumbai 400 012, India – sequence: 4 givenname: Shailesh surname: Pande fullname: Pande, Shailesh organization: ICMR-National Institute for Research in Reproductive and Child Health, Jehangir Merwanji Street, Parel, Mumbai 400 012, India – sequence: 5 givenname: Deepak N. orcidid: 0000-0002-4230-4219 surname: Modi fullname: Modi, Deepak N. organization: ICMR-National Institute for Research in Reproductive and Child Health, Jehangir Merwanji Street, Parel, Mumbai 400 012, India – sequence: 6 givenname: Amrita surname: Mehta fullname: Mehta, Amrita organization: Bai Jerbai Wadia Hospital For Children, Acharya Donde Marg, Parel, Mumbai 400 012, India – sequence: 7 givenname: Shweta surname: Bombe fullname: Bombe, Shweta organization: ICMR-National Institute for Research in Reproductive and Child Health, Jehangir Merwanji Street, Parel, Mumbai 400 012, India – sequence: 8 givenname: Bhakti R. orcidid: 0000-0002-6914-2491 surname: Pathak fullname: Pathak, Bhakti R. organization: ICMR-National Institute for Research in Reproductive and Child Health, Jehangir Merwanji Street, Parel, Mumbai 400 012, India – sequence: 9 givenname: Beena surname: Joshi fullname: Joshi, Beena organization: ICMR-National Institute for Research in Reproductive and Child Health, Jehangir Merwanji Street, Parel, Mumbai 400 012, India – sequence: 10 givenname: Deepti surname: Tandon fullname: Tandon, Deepti organization: ICMR-National Institute for Research in Reproductive and Child Health, Jehangir Merwanji Street, Parel, Mumbai 400 012, India – sequence: 11 givenname: Anushree surname: Patil fullname: Patil, Anushree organization: ICMR-National Institute for Research in Reproductive and Child Health, Jehangir Merwanji Street, Parel, Mumbai 400 012, India – sequence: 12 givenname: Shahina orcidid: 0000-0001-5590-2210 surname: Begum fullname: Begum, Shahina organization: ICMR-National Institute for Research in Reproductive and Child Health, Jehangir Merwanji Street, Parel, Mumbai 400 012, India – sequence: 13 givenname: Sanjay surname: Chauhan fullname: Chauhan, Sanjay organization: ICMR-National Institute for Research in Reproductive and Child Health, Jehangir Merwanji Street, Parel, Mumbai 400 012, India – sequence: 14 givenname: Smita D. orcidid: 0000-0002-4164-7455 surname: Mahale fullname: Mahale, Smita D. organization: ICMR-National Institute for Research in Reproductive and Child Health, Jehangir Merwanji Street, Parel, Mumbai 400 012, India – sequence: 15 givenname: Sudha surname: Rao fullname: Rao, Sudha email: c_sudha@hotmail.com organization: Bai Jerbai Wadia Hospital For Children, Acharya Donde Marg, Parel, Mumbai 400 012, India – sequence: 16 givenname: Suchitra V. orcidid: 0000-0002-8678-7144 surname: Surve fullname: Surve, Suchitra V. email: surves@nirrch.res.in, dr.suchi172@gmail.com organization: ICMR-National Institute for Research in Reproductive and Child Health, Jehangir Merwanji Street, Parel, Mumbai 400 012, India |
BookMark | eNp9kEtLxDAQx4MouKt-AU85eumaRx8JeBHxsbgg-DhKSJNpzdpNa9IKfnuz1LNzGRj-v2Hmt0SHvveA0DklK0poebldteBhxQjjK5qLNDpACyoqmRHCxSFaEF6JjFIqj9Eyxi1JVRRsgd6foYNv7Q3gvsF6anfgR7D408U4wDA6j6Nrve6cb_H4Efqp_cAPvMzx4_rlhT7jFDAJCbrDQwDTG9dPEQ9TDWH8OUVHje4inP31E_R2d_t685Btnu7XN9ebzLCSj1kDQlILxOi65lUhmZUEitzmeVkbURayYk1tc1NJaYtKWsZrLoQuGKtqqynhJ-hi3juE_muCOKqdiwa6TntI5ygmJCOUcZ6nKJujJvQxBmjUENxOhx9Fidq7VFu1d6n2LtXsMkFXMwTpiW8HQUXjIEmzLv08Ktu7__Bf8iF-0A |
CitedBy_id | crossref_primary_10_3390_genes15060788 |
Cites_doi | 10.1016/j.mce.2016.11.020 10.1038/nmeth.2890 10.1186/s13052-020-0808-6 10.1038/nmeth0410-248 10.1101/gr.3804205 10.1126/science.1853201 10.1210/er.2002-0019 10.1210/jc.2013-1024 10.1155/2016/6790794 10.1074/jbc.M104847200 10.1016/S2213-8587(15)00380-0 10.6065/jkspe.2011.16.1.38 10.3892/etm.2015.2398 10.1002/1096-9861(20001127)427:4<593::AID-CNE7>3.0.CO;2-C 10.2174/138161281939131127142531 10.1016/j.crmeth.2021.100014 10.1159/000126508 10.1074/jbc.M805251200 10.3346/jkms.2017.32.1.108 10.1073/pnas.1012406108 10.1210/en.2010-0903 10.1006/bbrc.1994.1565 10.1007/s40618-015-0277-8 10.1002/elps.1150181505 10.3345/cep.2021.00521 10.1523/JNEUROSCI.5828-09.2010 10.1515/jpem-2013-0080 10.1210/en.2012-1545 10.1523/JNEUROSCI.1569-09.2009 10.1186/s13052-019-0601-6 10.1016/0263-7855(90)80070-V 10.1038/35079135 10.1210/me.2009-0013 10.1515/jpem-2011-0445 10.1159/000493406 10.1016/j.cppeds.2006.10.005 10.1530/JME-14-0275 10.1016/j.peptides.2014.12.011 10.1056/NEJMcp0800459 10.5114/pedm.2020.103112 10.1093/humupd/dmu009 10.1210/jc.2009-2421 10.1210/jc.2004-1418 10.4274/jcrpe.4677 10.4103/2230-8210.149316 10.1093/nar/gkg509 10.3346/jkms.2011.26.7.927 10.1111/j.1365-2265.2009.03575.x 10.4274/jcrpe.3817 10.1038/356083a0 10.1056/NEJMoa073443 |
ContentType | Journal Article |
Copyright | 2023 Elsevier B.V. |
Copyright_xml | – notice: 2023 Elsevier B.V. |
DBID | AAYXX CITATION 7X8 |
DOI | 10.1016/j.gene.2023.148016 |
DatabaseName | CrossRef MEDLINE - Academic |
DatabaseTitle | CrossRef MEDLINE - Academic |
DatabaseTitleList | MEDLINE - Academic |
DeliveryMethod | fulltext_linktorsrc |
Discipline | Engineering Anatomy & Physiology Biology |
EISSN | 1879-0038 |
EndPage | 148016 |
ExternalDocumentID | 10_1016_j_gene_2023_148016 S0378111923008570 |
GroupedDBID | --- --K --M -~X .~1 0R~ 1B1 1RT 1~. 1~5 4.4 457 4G. 5GY 5VS 7-5 71M 8P~ 9JM AABNK AACTN AAEDT AAEDW AAIAV AAIKJ AAKOC AALRI AAOAW AAQFI AAXUO ABFNM ABFRF ABGSF ABJNI ABLJU ABMAC ABMYL ABUDA ABYKQ ACDAQ ACGFO ACGFS ACIUM ACNCT ACRLP ADBBV ADEZE ADUVX AEBSH AEFWE AEHWI AEKER AENEX AFKWA AFTJW AFXIZ AGHFR AGUBO AGYEJ AHHHB AIEXJ AIKHN AITUG AJOXV AKRWK ALMA_UNASSIGNED_HOLDINGS AMFUW AMRAJ AXJTR BKOJK BLXMC CS3 DOVZS DU5 EBS EFJIC EFLBG EO8 EO9 EP2 EP3 F5P FDB FIRID FNPLU FYGXN G-Q GBLVA IHE J1W KOM LX3 M41 MO0 N9A O-L O9- OAUVE OZT P-8 P-9 P2P PC. Q38 RIG ROL RPZ SCC SDF SDG SDP SES SEW SPCBC SSU SSZ T5K WH7 ZA5 ~G- .55 .GJ 0SF 29H 53G AAHBH AAQXK AAXKI AAYXX ABEFU ABXDB ADIYS ADMUD ADVLN AFJKZ AGRDE AI. ASPBG AVWKF AZFZN CITATION EJD FEDTE FGOYB G-2 G8K HLW HVGLF HZ~ MVM R2- SBG VH1 WUQ X7M XOL XPP Y6R ZGI ~KM 7X8 |
ID | FETCH-LOGICAL-c263t-fe891de0cabb37592d90e54d446bc865972fbd4c799d579d23b388a5227bda103 |
IEDL.DBID | .~1 |
ISSN | 0378-1119 |
IngestDate | Wed Aug 07 12:10:36 EDT 2024 Thu Sep 26 16:55:19 EDT 2024 Sat Mar 23 16:41:05 EDT 2024 |
IsPeerReviewed | true |
IsScholarly | true |
Keywords | Neuropeptide Y PP SDS NKB DLK1 Kisspeptin Neurokinin B Kp-10 NPY ICPP KISS1R MKRN3 FSH Nonsynonymous variant GnRH LH Central precocious puberty GnRHa |
Language | English |
LinkModel | DirectLink |
MergedId | FETCHMERGED-LOGICAL-c263t-fe891de0cabb37592d90e54d446bc865972fbd4c799d579d23b388a5227bda103 |
Notes | ObjectType-Case Study-2 SourceType-Scholarly Journals-1 ObjectType-Feature-4 content type line 23 ObjectType-Report-1 ObjectType-Article-3 |
ORCID | 0000-0002-4164-7455 0000-0001-5590-2210 0000-0002-6914-2491 0000-0002-8678-7144 0000-0002-4230-4219 |
PQID | 2892012334 |
PQPubID | 23479 |
PageCount | 1 |
ParticipantIDs | proquest_miscellaneous_2892012334 crossref_primary_10_1016_j_gene_2023_148016 elsevier_sciencedirect_doi_10_1016_j_gene_2023_148016 |
PublicationCentury | 2000 |
PublicationDate | 2024-02-15 |
PublicationDateYYYYMMDD | 2024-02-15 |
PublicationDate_xml | – month: 02 year: 2024 text: 2024-02-15 day: 15 |
PublicationDecade | 2020 |
PublicationTitle | Gene |
PublicationYear | 2024 |
Publisher | Elsevier B.V |
Publisher_xml | – name: Elsevier B.V |
References | Ohtaki, Shintani, Honda, Matsumoto, Hori, Kanehashi, Terao, Kumano, Takatsu, Masuda (b0155) 2001; 411 164–170. (doi:10.1126/SCIENCE.1853201). Hrabovszky, Sipos, Molnár, Ciofi, Borsay, Gergely, Herczeg, Bloom, Ghatei, Dhillo (b0095) 2012; 153 22693–22698. (doi:10.1073/PNAS.1012406108/SUPPL_FILE/PNAS.201012406SI.PDF). Adzhubei, Schmidt, Peshkin, Ramensky, Gerasimova, Bork, Kondrashov, Sunyaev (b0010) 2010; 7 De Vries, Shtaif, Phillip, Gat-Yablonski (b0050) 2009; 71 Banerjee, Dupakuntla, Pathak, Mahale (b0020) 2015; 54 Dixit, Jaiswal, Usmani, Chaudhary (bib257) 2021; 27 Guex, Peitsch (b0090) 1997; 18 Zheng, Zhang, Li, Pearce, Bell, Zhang (b0250) 2021; 1 Ko, Lee, Lee, Hwang (b0100) 2011; 16 ‘PyMOL | pymol.org’. Pampillo M, Camuso N, Taylor JE, Szereszewski JM, Ahow MR, Zajac M, Millar RP, Bhattacharya M & Babwah A V. 2009 Regulation of GPR54 signaling by GRK2 and {beta}-arrestin. Bowie JU, Lüthy R & Eisenberg D 1991 A method to identify protein sequences that fold into a known three-dimensional structure. Yang, Xiong, Yang, Xie, Huang (b0245) 2015; 9 Banerjee, Achrekar, Joseph, Pathak, Mahale (b0025) 2017; 440 Abaci, Çatli, Anik, Küme, Çalan, Dündar, Böber (b0005) 2015; 64 Altıncık, Sayın (b0015) 2018; 10 Wacker, Feller, Tang, DeFino, Namkung, Lyssand, Mhyre, Tan, Jensen, Hague (b0235) 2008; 283 Ghaemi, Ghahraman, Noroozi Asl, Vakili, Fardi Golyan, Moghbeli, Abbaszadegan (b0080) 2019; 45 Dudás, Mihály, Merchenthaler (b0060) 2000; 427 Trevisan, Montagna, De Oliveira, Christofolini, Barbosa, Crandall, Bianco (b0225) 2018; 49 Nebesio, Eugster (b0140) 2007; 37 Parlak, Türkkahraman, Ellidağ, Çelmeli, Parlak, Yılmaz (b0175) 2017; 9 Kumar, Mukhopadhyay, Dutta (b0115) 2015; 19 García-Galiano, Tena-Sempere (b0075) 2013; 19 Krstevska-Konstantinova, Jovanovska, Tasic, Montenegro, Beneduzzi, Silveira, Gucev (b0110) 2014; 27 Navarro, Gottsch, Chavkin, Okamura, Clifton, Steiner (b0135) 2009; 29 Pagani, Calcaterra, Acquafredda, Montalbano, Bozzola, Ferrara, Gasparri, Villani, Bozzola (b0160) 2020; 46 Ng, Henikoff (b0145) 2003; 31 Semple, Achermann, Ellery, Farooqi, Karet, Stanhope, O’Rahilly, Aparicio (b0195) 2005; 90 García-Galiano, Navarro, Roa, Ruiz-Pino, Sánchez-Garrido, Pineda, Castellano, Romero, Aguilar, Gaytán (b0070) 2010; 30 Bianco, Vandepas, Correa-Medina, Gereben, Mukherjee, Kuohung, Carroll, Teles, Latronico, Kaiser (b0030) 2011; 152 Shim, Lee, Hwang (b0200) 2022; 65 Fuqua (b0065) 2013; 98 Vriend (b0230) 1990; 8 Gore, Mitsushima, Terasawa (b0085) 1993; 58 Zhu, Li, Pan, Li, Zhang, Wang, Yang, Wu, Gong (b0255) 2016; 2016 Teles, Bianco, Brito, Trarbach, Kuohung, Xu, Seminara, Mendonca, Kaiser, Latronico (b0220) 2008; 358 Watanobe, Nigawara, Anzai, Sakihara, Kageyama, Nasushita, Sasaki, Habu, Takebe (b0240) 1994; 200 Latronico, Brito, Carel (b0120) 2016; 4 Carel, Léger (b0040) 2008; 358 Skorupskaite, George, Anderson (b0210) 2014; 20 Çatll, Anlk, Küme, Çalan, Dündar, Böber, Abacl (b0045) 2015; 38 Silveira, Noel, Silveira-Neto, Abreu, Brito, Santos, Bianco, Kuohung, Xu, Gryngarten (b0205) 2010; 95 Demirbilek, Gonc, Ozon, Alikasifoglu, Kandemir (b0055) 2012; 25 Lüthy, Bowie, Eisenberg (b0125) 1992; 356 Parent, Teilmann, Juul, Skakkebaek, Toppari, Bourguignon (b0170) 2003; 24 Rhie, Lee, Eun, Choi, Chae, Kwon, Lee, Kim, Kim (b0185) 2011; 26 Oh, Rhie, Nam, Kim, Lee (b0150) 2017; 32 2060–2074. (doi:10.1210/ME.2009-0013). Stone, Sidow (b0215) 2005; 15 Khadilkar, Khadilkar, Kinare, Tapasvi, Deshpande, Maskati (bib256) 2006; 43 Kotani, Detheux, Vandenbogaerde, Communi, Vanderwinden, Le Poul, Brézillon, Tyldesley, Suarez-Huerta, Vandeput (b0105) 2001; 276 Schwarz, Cooper, Schuelke, Seelow (b0190) 2014; 11 Mayer C, Acosta-Martinez M, Dubois SL, Wolfe A, Radovick S, Boehm U & Levine JE 2010 Timing and completion of puberty in female mice depend on estrogen receptor α-signaling in kisspeptin neurons. Banerjee (10.1016/j.gene.2023.148016_b0020) 2015; 54 Zheng (10.1016/j.gene.2023.148016_b0250) 2021; 1 Silveira (10.1016/j.gene.2023.148016_b0205) 2010; 95 Bianco (10.1016/j.gene.2023.148016_b0030) 2011; 152 Semple (10.1016/j.gene.2023.148016_b0195) 2005; 90 Ohtaki (10.1016/j.gene.2023.148016_b0155) 2001; 411 Kotani (10.1016/j.gene.2023.148016_b0105) 2001; 276 Zhu (10.1016/j.gene.2023.148016_b0255) 2016; 2016 Dixit (10.1016/j.gene.2023.148016_bib257) 2021; 27 Altıncık (10.1016/j.gene.2023.148016_b0015) 2018; 10 Hrabovszky (10.1016/j.gene.2023.148016_b0095) 2012; 153 Adzhubei (10.1016/j.gene.2023.148016_b0010) 2010; 7 Teles (10.1016/j.gene.2023.148016_b0220) 2008; 358 10.1016/j.gene.2023.148016_b0035 Pagani (10.1016/j.gene.2023.148016_b0160) 2020; 46 Kumar (10.1016/j.gene.2023.148016_b0115) 2015; 19 Rhie (10.1016/j.gene.2023.148016_b0185) 2011; 26 Ko (10.1016/j.gene.2023.148016_b0100) 2011; 16 Banerjee (10.1016/j.gene.2023.148016_b0025) 2017; 440 Lüthy (10.1016/j.gene.2023.148016_b0125) 1992; 356 Schwarz (10.1016/j.gene.2023.148016_b0190) 2014; 11 Khadilkar (10.1016/j.gene.2023.148016_bib256) 2006; 43 Fuqua (10.1016/j.gene.2023.148016_b0065) 2013; 98 Watanobe (10.1016/j.gene.2023.148016_b0240) 1994; 200 Ghaemi (10.1016/j.gene.2023.148016_b0080) 2019; 45 Wacker (10.1016/j.gene.2023.148016_b0235) 2008; 283 10.1016/j.gene.2023.148016_b0165 Nebesio (10.1016/j.gene.2023.148016_b0140) 2007; 37 Stone (10.1016/j.gene.2023.148016_b0215) 2005; 15 De Vries (10.1016/j.gene.2023.148016_b0050) 2009; 71 Çatll (10.1016/j.gene.2023.148016_b0045) 2015; 38 García-Galiano (10.1016/j.gene.2023.148016_b0075) 2013; 19 Abaci (10.1016/j.gene.2023.148016_b0005) 2015; 64 García-Galiano (10.1016/j.gene.2023.148016_b0070) 2010; 30 Latronico (10.1016/j.gene.2023.148016_b0120) 2016; 4 Krstevska-Konstantinova (10.1016/j.gene.2023.148016_b0110) 2014; 27 Dudás (10.1016/j.gene.2023.148016_b0060) 2000; 427 10.1016/j.gene.2023.148016_b0130 Shim (10.1016/j.gene.2023.148016_b0200) 2022; 65 Ng (10.1016/j.gene.2023.148016_b0145) 2003; 31 Parent (10.1016/j.gene.2023.148016_b0170) 2003; 24 Parlak (10.1016/j.gene.2023.148016_b0175) 2017; 9 Gore (10.1016/j.gene.2023.148016_b0085) 1993; 58 Skorupskaite (10.1016/j.gene.2023.148016_b0210) 2014; 20 Guex (10.1016/j.gene.2023.148016_b0090) 1997; 18 Vriend (10.1016/j.gene.2023.148016_b0230) 1990; 8 Demirbilek (10.1016/j.gene.2023.148016_b0055) 2012; 25 Yang (10.1016/j.gene.2023.148016_b0245) 2015; 9 10.1016/j.gene.2023.148016_b0180 Navarro (10.1016/j.gene.2023.148016_b0135) 2009; 29 Carel (10.1016/j.gene.2023.148016_b0040) 2008; 358 Oh (10.1016/j.gene.2023.148016_b0150) 2017; 32 Trevisan (10.1016/j.gene.2023.148016_b0225) 2018; 49 |
References_xml | – volume: 27 start-page: 37 year: 2021 end-page: 41 ident: bib257 article-title: Uterine and ovarian parameters in healthy North Indian girls from 5 to 16 years by ultrasonography publication-title: Pediatric Endocrinology, Diabetes and Metabolism contributor: fullname: Chaudhary – volume: 90 start-page: 1849 year: 2005 end-page: 1855 ident: b0195 article-title: Two novel missense mutations in g protein-coupled receptor 54 in a patient with hypogonadotropic hypogonadism publication-title: J. Clin. Endocrinol. Metab. contributor: fullname: Aparicio – volume: 19 start-page: 228 year: 2015 ident: b0115 article-title: Challenges and controversies in diagnosis and management of gonadotropin dependent precocious puberty: An Indian perspective publication-title: Indian Journal of Endocrinology and Metabolism contributor: fullname: Dutta – volume: 46 start-page: 1 year: 2020 end-page: 6 ident: b0160 article-title: MKRN3 and KISS1R mutations in precocious and early puberty publication-title: Ital. J. Pediatr. contributor: fullname: Bozzola – volume: 358 start-page: 2366 year: 2008 end-page: 2377 ident: b0040 article-title: Clinical practice. Precocious puberty publication-title: N. Engl. J. Med. contributor: fullname: Léger – volume: 427 start-page: 593 year: 2000 end-page: 603 ident: b0060 article-title: Topography and associations of luteinizing hormone-releasing hormone and neuropeptide Y-immunoreactive neuronal systems in the human diencephalon publication-title: J Comp Neurol contributor: fullname: Merchenthaler – volume: 356 start-page: 83 year: 1992 end-page: 85 ident: b0125 article-title: Assessment of protein models with three-dimensional profiles publication-title: Nature contributor: fullname: Eisenberg – volume: 440 start-page: 69 year: 2017 end-page: 79 ident: b0025 article-title: Functional characterization of two naturally occurring mutations V221G and T449N in the follicle stimulating hormone receptor publication-title: Mol. Cell. Endocrinol. contributor: fullname: Mahale – volume: 32 start-page: 108 year: 2017 end-page: 114 ident: b0150 article-title: Genetic variations of the KISS1R gene in korean girls with central precocious puberty publication-title: J. Korean Med. Sci. contributor: fullname: Lee – volume: 358 start-page: 709 year: 2008 end-page: 715 ident: b0220 article-title: A GPR54-activating mutation in a patient with central precocious puberty publication-title: N. Engl. J. Med. contributor: fullname: Latronico – volume: 2016 year: 2016 ident: b0255 article-title: The Changes of Serum Leptin and Kisspeptin Levels in Chinese Children and Adolescents in Different Pubertal Stages publication-title: Int. J. Endocrinol. contributor: fullname: Gong – volume: 95 start-page: 2276 year: 2010 end-page: 2280 ident: b0205 article-title: Mutations of the KISS1 gene in disorders of puberty publication-title: J. Clin. Endocrinol. Metab. contributor: fullname: Gryngarten – volume: 15 start-page: 978 year: 2005 end-page: 986 ident: b0215 article-title: Physicochemical constraint violation by missense substitutions mediates impairment of protein function and disease severity publication-title: Genome Res. contributor: fullname: Sidow – volume: 37 start-page: 50 year: 2007 end-page: 72 ident: b0140 article-title: Current concepts in normal and abnormal puberty publication-title: Curr. Probl. Pediatr. Adolesc. Health Care contributor: fullname: Eugster – volume: 283 start-page: 31068 year: 2008 ident: b0235 article-title: Disease-causing Mutation in GPR54 Reveals the Importance of the Second Intracellular Loop for Class A G-protein-coupled Receptor Function publication-title: J. Biol. Chem. contributor: fullname: Hague – volume: 54 start-page: 193 year: 2015 end-page: 204 ident: b0020 article-title: FSH receptor-specific residues L501 and I505 in extracellular loop 2 are essential for its function publication-title: J. Mol. Endocrinol. contributor: fullname: Mahale – volume: 18 start-page: 2714 year: 1997 end-page: 2723 ident: b0090 article-title: SWISS-MODEL and the Swiss-PdbViewer: an environment for comparative protein modeling publication-title: Electrophoresis contributor: fullname: Peitsch – volume: 71 start-page: 524 year: 2009 end-page: 528 ident: b0050 article-title: Kisspeptin serum levels in girls with central precocious puberty publication-title: Clin. Endocrinol. contributor: fullname: Gat-Yablonski – volume: 16 start-page: 38 year: 2011 ident: b0100 article-title: Genetic Variations of GNRH1, GNRHR and GPR54 Genes in Korean Girls with Central Precocious Puberty publication-title: Journal of Korean Society of Pediatric Endocrinology contributor: fullname: Hwang – volume: 10 start-page: 8 year: 2018 end-page: 12 ident: b0015 article-title: Serum Nesfatin-1 Levels in Girls with Idiopathic Central Precocious Puberty publication-title: J. Clin. Res. Pediatr. Endocrinol. contributor: fullname: Sayın – volume: 9 start-page: 2369 year: 2015 ident: b0245 article-title: Testing of kisspeptin levels in girls with idiopathic central precocious puberty and its significance publication-title: Exp. Ther. Med. contributor: fullname: Huang – volume: 98 start-page: 2198 year: 2013 end-page: 2207 ident: b0065 article-title: Treatment and outcomes of precocious puberty: an update publication-title: J. Clin. Endocrinol. Metab. contributor: fullname: Fuqua – volume: 9 start-page: 101 year: 2017 end-page: 105 ident: b0175 article-title: Basal Serum Neurokinin B Levels in Differentiating Idiopathic Central Precocious Puberty from Premature Thelarche publication-title: J. Clin. Res. Pediatr. Endocrinol. contributor: fullname: Yılmaz – volume: 26 start-page: 927 year: 2011 end-page: 931 ident: b0185 article-title: Serum kisspeptin levels in Korean girls with central precocious puberty publication-title: J. Korean Med. Sci. contributor: fullname: Kim – volume: 11 start-page: 361 year: 2014 end-page: 362 ident: b0190 article-title: MutationTaster2: mutation prediction for the deep-sequencing age publication-title: Nat. Methods contributor: fullname: Seelow – volume: 19 start-page: 6966 year: 2013 end-page: 6972 ident: b0075 article-title: Emerging roles of NUCB2/nesfatin-1 in the metabolic control of reproduction publication-title: Curr. Pharm. Des. contributor: fullname: Tena-Sempere – volume: 65 start-page: 172 year: 2022 end-page: 181 ident: b0200 article-title: Genetic factors in precocious puberty publication-title: Clinical and Experimental Pediatrics contributor: fullname: Hwang – volume: 58 start-page: 23 year: 1993 end-page: 34 ident: b0085 article-title: A Possible Role of Neuropeptide Y in the Control of the Onset of Puberty in Female Rhesus Monkeys publication-title: Neuroendocrinology contributor: fullname: Terasawa – volume: 4 start-page: 265 year: 2016 end-page: 274 ident: b0120 article-title: Causes, diagnosis, and treatment of central precocious puberty publication-title: Lancet Diabetes Endocrinol. contributor: fullname: Carel – volume: 411 start-page: 613 year: 2001 end-page: 617 ident: b0155 article-title: Metastasis suppressor gene KiSS-1 encodes peptide ligand of a G-protein-coupled receptor publication-title: Nature contributor: fullname: Masuda – volume: 20 start-page: 485 year: 2014 ident: b0210 article-title: The kisspeptin-GnRH pathway in human reproductive health and disease publication-title: Hum. Reprod. Update contributor: fullname: Anderson – volume: 24 start-page: 668 year: 2003 end-page: 693 ident: b0170 article-title: The timing of normal puberty and the age limits of sexual precocity: variations around the world, secular trends, and changes after migration publication-title: Endocr. Rev. contributor: fullname: Bourguignon – volume: 64 start-page: 29 year: 2015 end-page: 33 ident: b0005 article-title: Significance of serum neurokinin B and kisspeptin levels in the differential diagnosis of premature thelarche and idiopathic central precocious puberty publication-title: Peptides contributor: fullname: Böber – volume: 1 year: 2021 ident: b0250 article-title: Folding non-homologous proteins by coupling deep-learning contact maps with I-TASSER assembly simulations publication-title: Cell Reports Methods contributor: fullname: Zhang – volume: 8 start-page: 52 year: 1990 end-page: 56 ident: b0230 article-title: WHAT IF: a molecular modeling and drug design program publication-title: J. Mol. Graph. contributor: fullname: Vriend – volume: 152 start-page: 1616 year: 2011 ident: b0030 article-title: KISS1R Intracellular Trafficking and Degradation: Effect of the Arg386Pro Disease-Associated Mutation publication-title: Endocrinology contributor: fullname: Kaiser – volume: 29 start-page: 11859 year: 2009 ident: b0135 article-title: Regulation of Gonadotropin-Releasing Hormone Secretion by Kisspeptin/Dynorphin/Neurokinin B Neurons in the Arcuate Nucleus of the Mouse publication-title: J. Neurosci. contributor: fullname: Steiner – volume: 49 start-page: 1259 year: 2018 end-page: 1276 ident: b0225 article-title: Kisspeptin/GPR54 System: What Do We Know About Its Role in Human Reproduction? publication-title: Cell. Physiol. Biochem. contributor: fullname: Bianco – volume: 276 start-page: 34631 year: 2001 end-page: 34636 ident: b0105 article-title: The metastasis suppressor gene KiSS-1 encodes kisspeptins, the natural ligands of the orphan G protein-coupled receptor GPR54 publication-title: J. Biol. Chem. contributor: fullname: Vandeput – volume: 38 start-page: 909 year: 2015 end-page: 913 ident: b0045 article-title: Serum nesfatin-1 and leptin levels in non-obese girls with premature thelarche publication-title: J. Endocrinol. Invest. contributor: fullname: Abacl – volume: 27 start-page: 199 year: 2014 end-page: 201 ident: b0110 article-title: Mutational analysis of KISS1 and KISS1R in idiopathic central precocious puberty publication-title: Journal of Pediatric Endocrinology & Metabolism : JPEM contributor: fullname: Gucev – volume: 7 start-page: 248 year: 2010 end-page: 249 ident: b0010 article-title: A method and server for predicting damaging missense mutations publication-title: Nat. Methods contributor: fullname: Sunyaev – volume: 25 start-page: 313 year: 2012 end-page: 316 ident: b0055 article-title: Evaluation of serum kisspeptin levels in girls in the diagnosis of central precocious puberty and in the assessment of pubertal suppression publication-title: Journal of Pediatric Endocrinology & Metabolism : JPEM contributor: fullname: Kandemir – volume: 30 start-page: 7783 year: 2010 ident: b0070 article-title: The Anorexigenic Neuropeptide, Nesfatin-1, Is Indispensable for Normal Puberty Onset in the Female Rat publication-title: J. Neurosci. contributor: fullname: Gaytán – volume: 43 start-page: 625 year: 2006 end-page: 630 ident: bib256 article-title: Ovarian and uterine ultrasonography in healthy girls between birth to 18 years publication-title: Indian Pediatrics contributor: fullname: Maskati – volume: 45 year: 2019 ident: b0080 article-title: Novel DNA variation of GPR54 gene in familial central precocious puberty publication-title: Ital. J. Pediatr. contributor: fullname: Abbaszadegan – volume: 153 start-page: 4978 year: 2012 end-page: 4989 ident: b0095 article-title: Low degree of overlap between kisspeptin, neurokinin B, and dynorphin immunoreactivities in the infundibular nucleus of young male human subjects challenges the KNDy neuron concept publication-title: Endocrinology contributor: fullname: Dhillo – volume: 200 start-page: 1111 year: 1994 end-page: 1117 ident: b0240 article-title: Neuropeptide Y Potentiates the Luteinizing Hormone (LH) Response to LH-Releasing Hormone in Men publication-title: Biochem. Biophys. Res. Commun. contributor: fullname: Takebe – volume: 31 start-page: 3812 year: 2003 end-page: 3814 ident: b0145 article-title: SIFT: Predicting amino acid changes that affect protein function publication-title: Nucleic Acids Res. contributor: fullname: Henikoff – volume: 440 start-page: 69 year: 2017 ident: 10.1016/j.gene.2023.148016_b0025 article-title: Functional characterization of two naturally occurring mutations V221G and T449N in the follicle stimulating hormone receptor publication-title: Mol. Cell. Endocrinol. doi: 10.1016/j.mce.2016.11.020 contributor: fullname: Banerjee – volume: 11 start-page: 361 year: 2014 ident: 10.1016/j.gene.2023.148016_b0190 article-title: MutationTaster2: mutation prediction for the deep-sequencing age publication-title: Nat. Methods doi: 10.1038/nmeth.2890 contributor: fullname: Schwarz – volume: 46 start-page: 1 year: 2020 ident: 10.1016/j.gene.2023.148016_b0160 article-title: MKRN3 and KISS1R mutations in precocious and early puberty publication-title: Ital. J. Pediatr. doi: 10.1186/s13052-020-0808-6 contributor: fullname: Pagani – volume: 7 start-page: 248 year: 2010 ident: 10.1016/j.gene.2023.148016_b0010 article-title: A method and server for predicting damaging missense mutations publication-title: Nat. Methods doi: 10.1038/nmeth0410-248 contributor: fullname: Adzhubei – volume: 15 start-page: 978 year: 2005 ident: 10.1016/j.gene.2023.148016_b0215 article-title: Physicochemical constraint violation by missense substitutions mediates impairment of protein function and disease severity publication-title: Genome Res. doi: 10.1101/gr.3804205 contributor: fullname: Stone – ident: 10.1016/j.gene.2023.148016_b0035 doi: 10.1126/science.1853201 – volume: 24 start-page: 668 year: 2003 ident: 10.1016/j.gene.2023.148016_b0170 article-title: The timing of normal puberty and the age limits of sexual precocity: variations around the world, secular trends, and changes after migration publication-title: Endocr. Rev. doi: 10.1210/er.2002-0019 contributor: fullname: Parent – volume: 98 start-page: 2198 year: 2013 ident: 10.1016/j.gene.2023.148016_b0065 article-title: Treatment and outcomes of precocious puberty: an update publication-title: J. Clin. Endocrinol. Metab. doi: 10.1210/jc.2013-1024 contributor: fullname: Fuqua – volume: 2016 year: 2016 ident: 10.1016/j.gene.2023.148016_b0255 article-title: The Changes of Serum Leptin and Kisspeptin Levels in Chinese Children and Adolescents in Different Pubertal Stages publication-title: Int. J. Endocrinol. doi: 10.1155/2016/6790794 contributor: fullname: Zhu – volume: 276 start-page: 34631 year: 2001 ident: 10.1016/j.gene.2023.148016_b0105 article-title: The metastasis suppressor gene KiSS-1 encodes kisspeptins, the natural ligands of the orphan G protein-coupled receptor GPR54 publication-title: J. Biol. Chem. doi: 10.1074/jbc.M104847200 contributor: fullname: Kotani – volume: 4 start-page: 265 year: 2016 ident: 10.1016/j.gene.2023.148016_b0120 article-title: Causes, diagnosis, and treatment of central precocious puberty publication-title: Lancet Diabetes Endocrinol. doi: 10.1016/S2213-8587(15)00380-0 contributor: fullname: Latronico – volume: 16 start-page: 38 year: 2011 ident: 10.1016/j.gene.2023.148016_b0100 article-title: Genetic Variations of GNRH1, GNRHR and GPR54 Genes in Korean Girls with Central Precocious Puberty publication-title: Journal of Korean Society of Pediatric Endocrinology doi: 10.6065/jkspe.2011.16.1.38 contributor: fullname: Ko – volume: 9 start-page: 2369 year: 2015 ident: 10.1016/j.gene.2023.148016_b0245 article-title: Testing of kisspeptin levels in girls with idiopathic central precocious puberty and its significance publication-title: Exp. Ther. Med. doi: 10.3892/etm.2015.2398 contributor: fullname: Yang – volume: 427 start-page: 593 year: 2000 ident: 10.1016/j.gene.2023.148016_b0060 article-title: Topography and associations of luteinizing hormone-releasing hormone and neuropeptide Y-immunoreactive neuronal systems in the human diencephalon publication-title: J Comp Neurol doi: 10.1002/1096-9861(20001127)427:4<593::AID-CNE7>3.0.CO;2-C contributor: fullname: Dudás – volume: 19 start-page: 6966 year: 2013 ident: 10.1016/j.gene.2023.148016_b0075 article-title: Emerging roles of NUCB2/nesfatin-1 in the metabolic control of reproduction publication-title: Curr. Pharm. Des. doi: 10.2174/138161281939131127142531 contributor: fullname: García-Galiano – volume: 1 year: 2021 ident: 10.1016/j.gene.2023.148016_b0250 article-title: Folding non-homologous proteins by coupling deep-learning contact maps with I-TASSER assembly simulations publication-title: Cell Reports Methods doi: 10.1016/j.crmeth.2021.100014 contributor: fullname: Zheng – volume: 58 start-page: 23 year: 1993 ident: 10.1016/j.gene.2023.148016_b0085 article-title: A Possible Role of Neuropeptide Y in the Control of the Onset of Puberty in Female Rhesus Monkeys publication-title: Neuroendocrinology doi: 10.1159/000126508 contributor: fullname: Gore – volume: 283 start-page: 31068 year: 2008 ident: 10.1016/j.gene.2023.148016_b0235 article-title: Disease-causing Mutation in GPR54 Reveals the Importance of the Second Intracellular Loop for Class A G-protein-coupled Receptor Function publication-title: J. Biol. Chem. doi: 10.1074/jbc.M805251200 contributor: fullname: Wacker – volume: 32 start-page: 108 year: 2017 ident: 10.1016/j.gene.2023.148016_b0150 article-title: Genetic variations of the KISS1R gene in korean girls with central precocious puberty publication-title: J. Korean Med. Sci. doi: 10.3346/jkms.2017.32.1.108 contributor: fullname: Oh – ident: 10.1016/j.gene.2023.148016_b0130 doi: 10.1073/pnas.1012406108 – volume: 43 start-page: 625 year: 2006 ident: 10.1016/j.gene.2023.148016_bib256 article-title: Ovarian and uterine ultrasonography in healthy girls between birth to 18 years publication-title: Indian Pediatrics contributor: fullname: Khadilkar – volume: 152 start-page: 1616 year: 2011 ident: 10.1016/j.gene.2023.148016_b0030 article-title: KISS1R Intracellular Trafficking and Degradation: Effect of the Arg386Pro Disease-Associated Mutation publication-title: Endocrinology doi: 10.1210/en.2010-0903 contributor: fullname: Bianco – volume: 200 start-page: 1111 year: 1994 ident: 10.1016/j.gene.2023.148016_b0240 article-title: Neuropeptide Y Potentiates the Luteinizing Hormone (LH) Response to LH-Releasing Hormone in Men publication-title: Biochem. Biophys. Res. Commun. doi: 10.1006/bbrc.1994.1565 contributor: fullname: Watanobe – volume: 38 start-page: 909 year: 2015 ident: 10.1016/j.gene.2023.148016_b0045 article-title: Serum nesfatin-1 and leptin levels in non-obese girls with premature thelarche publication-title: J. Endocrinol. Invest. doi: 10.1007/s40618-015-0277-8 contributor: fullname: Çatll – volume: 18 start-page: 2714 year: 1997 ident: 10.1016/j.gene.2023.148016_b0090 article-title: SWISS-MODEL and the Swiss-PdbViewer: an environment for comparative protein modeling publication-title: Electrophoresis doi: 10.1002/elps.1150181505 contributor: fullname: Guex – volume: 65 start-page: 172 year: 2022 ident: 10.1016/j.gene.2023.148016_b0200 article-title: Genetic factors in precocious puberty publication-title: Clinical and Experimental Pediatrics doi: 10.3345/cep.2021.00521 contributor: fullname: Shim – volume: 30 start-page: 7783 year: 2010 ident: 10.1016/j.gene.2023.148016_b0070 article-title: The Anorexigenic Neuropeptide, Nesfatin-1, Is Indispensable for Normal Puberty Onset in the Female Rat publication-title: J. Neurosci. doi: 10.1523/JNEUROSCI.5828-09.2010 contributor: fullname: García-Galiano – volume: 27 start-page: 199 year: 2014 ident: 10.1016/j.gene.2023.148016_b0110 article-title: Mutational analysis of KISS1 and KISS1R in idiopathic central precocious puberty publication-title: Journal of Pediatric Endocrinology & Metabolism : JPEM doi: 10.1515/jpem-2013-0080 contributor: fullname: Krstevska-Konstantinova – volume: 153 start-page: 4978 year: 2012 ident: 10.1016/j.gene.2023.148016_b0095 article-title: Low degree of overlap between kisspeptin, neurokinin B, and dynorphin immunoreactivities in the infundibular nucleus of young male human subjects challenges the KNDy neuron concept publication-title: Endocrinology doi: 10.1210/en.2012-1545 contributor: fullname: Hrabovszky – volume: 29 start-page: 11859 year: 2009 ident: 10.1016/j.gene.2023.148016_b0135 article-title: Regulation of Gonadotropin-Releasing Hormone Secretion by Kisspeptin/Dynorphin/Neurokinin B Neurons in the Arcuate Nucleus of the Mouse publication-title: J. Neurosci. doi: 10.1523/JNEUROSCI.1569-09.2009 contributor: fullname: Navarro – volume: 45 year: 2019 ident: 10.1016/j.gene.2023.148016_b0080 article-title: Novel DNA variation of GPR54 gene in familial central precocious puberty publication-title: Ital. J. Pediatr. doi: 10.1186/s13052-019-0601-6 contributor: fullname: Ghaemi – volume: 8 start-page: 52 year: 1990 ident: 10.1016/j.gene.2023.148016_b0230 article-title: WHAT IF: a molecular modeling and drug design program publication-title: J. Mol. Graph. doi: 10.1016/0263-7855(90)80070-V contributor: fullname: Vriend – volume: 411 start-page: 613 year: 2001 ident: 10.1016/j.gene.2023.148016_b0155 article-title: Metastasis suppressor gene KiSS-1 encodes peptide ligand of a G-protein-coupled receptor publication-title: Nature doi: 10.1038/35079135 contributor: fullname: Ohtaki – ident: 10.1016/j.gene.2023.148016_b0165 doi: 10.1210/me.2009-0013 – volume: 25 start-page: 313 year: 2012 ident: 10.1016/j.gene.2023.148016_b0055 article-title: Evaluation of serum kisspeptin levels in girls in the diagnosis of central precocious puberty and in the assessment of pubertal suppression publication-title: Journal of Pediatric Endocrinology & Metabolism : JPEM doi: 10.1515/jpem-2011-0445 contributor: fullname: Demirbilek – volume: 49 start-page: 1259 year: 2018 ident: 10.1016/j.gene.2023.148016_b0225 article-title: Kisspeptin/GPR54 System: What Do We Know About Its Role in Human Reproduction? publication-title: Cell. Physiol. Biochem. doi: 10.1159/000493406 contributor: fullname: Trevisan – volume: 37 start-page: 50 year: 2007 ident: 10.1016/j.gene.2023.148016_b0140 article-title: Current concepts in normal and abnormal puberty publication-title: Curr. Probl. Pediatr. Adolesc. Health Care doi: 10.1016/j.cppeds.2006.10.005 contributor: fullname: Nebesio – volume: 54 start-page: 193 year: 2015 ident: 10.1016/j.gene.2023.148016_b0020 article-title: FSH receptor-specific residues L501 and I505 in extracellular loop 2 are essential for its function publication-title: J. Mol. Endocrinol. doi: 10.1530/JME-14-0275 contributor: fullname: Banerjee – volume: 64 start-page: 29 year: 2015 ident: 10.1016/j.gene.2023.148016_b0005 article-title: Significance of serum neurokinin B and kisspeptin levels in the differential diagnosis of premature thelarche and idiopathic central precocious puberty publication-title: Peptides doi: 10.1016/j.peptides.2014.12.011 contributor: fullname: Abaci – volume: 358 start-page: 2366 year: 2008 ident: 10.1016/j.gene.2023.148016_b0040 article-title: Clinical practice. Precocious puberty publication-title: N. Engl. J. Med. doi: 10.1056/NEJMcp0800459 contributor: fullname: Carel – volume: 27 start-page: 37 year: 2021 ident: 10.1016/j.gene.2023.148016_bib257 article-title: Uterine and ovarian parameters in healthy North Indian girls from 5 to 16 years by ultrasonography publication-title: Pediatric Endocrinology, Diabetes and Metabolism doi: 10.5114/pedm.2020.103112 contributor: fullname: Dixit – volume: 20 start-page: 485 year: 2014 ident: 10.1016/j.gene.2023.148016_b0210 article-title: The kisspeptin-GnRH pathway in human reproductive health and disease publication-title: Hum. Reprod. Update doi: 10.1093/humupd/dmu009 contributor: fullname: Skorupskaite – volume: 95 start-page: 2276 year: 2010 ident: 10.1016/j.gene.2023.148016_b0205 article-title: Mutations of the KISS1 gene in disorders of puberty publication-title: J. Clin. Endocrinol. Metab. doi: 10.1210/jc.2009-2421 contributor: fullname: Silveira – volume: 90 start-page: 1849 year: 2005 ident: 10.1016/j.gene.2023.148016_b0195 article-title: Two novel missense mutations in g protein-coupled receptor 54 in a patient with hypogonadotropic hypogonadism publication-title: J. Clin. Endocrinol. Metab. doi: 10.1210/jc.2004-1418 contributor: fullname: Semple – volume: 10 start-page: 8 year: 2018 ident: 10.1016/j.gene.2023.148016_b0015 article-title: Serum Nesfatin-1 Levels in Girls with Idiopathic Central Precocious Puberty publication-title: J. Clin. Res. Pediatr. Endocrinol. doi: 10.4274/jcrpe.4677 contributor: fullname: Altıncık – volume: 19 start-page: 228 year: 2015 ident: 10.1016/j.gene.2023.148016_b0115 article-title: Challenges and controversies in diagnosis and management of gonadotropin dependent precocious puberty: An Indian perspective publication-title: Indian Journal of Endocrinology and Metabolism doi: 10.4103/2230-8210.149316 contributor: fullname: Kumar – volume: 31 start-page: 3812 year: 2003 ident: 10.1016/j.gene.2023.148016_b0145 article-title: SIFT: Predicting amino acid changes that affect protein function publication-title: Nucleic Acids Res. doi: 10.1093/nar/gkg509 contributor: fullname: Ng – volume: 26 start-page: 927 year: 2011 ident: 10.1016/j.gene.2023.148016_b0185 article-title: Serum kisspeptin levels in Korean girls with central precocious puberty publication-title: J. Korean Med. Sci. doi: 10.3346/jkms.2011.26.7.927 contributor: fullname: Rhie – ident: 10.1016/j.gene.2023.148016_b0180 – volume: 71 start-page: 524 year: 2009 ident: 10.1016/j.gene.2023.148016_b0050 article-title: Kisspeptin serum levels in girls with central precocious puberty publication-title: Clin. Endocrinol. doi: 10.1111/j.1365-2265.2009.03575.x contributor: fullname: De Vries – volume: 9 start-page: 101 year: 2017 ident: 10.1016/j.gene.2023.148016_b0175 article-title: Basal Serum Neurokinin B Levels in Differentiating Idiopathic Central Precocious Puberty from Premature Thelarche publication-title: J. Clin. Res. Pediatr. Endocrinol. doi: 10.4274/jcrpe.3817 contributor: fullname: Parlak – volume: 356 start-page: 83 year: 1992 ident: 10.1016/j.gene.2023.148016_b0125 article-title: Assessment of protein models with three-dimensional profiles publication-title: Nature doi: 10.1038/356083a0 contributor: fullname: Lüthy – volume: 358 start-page: 709 year: 2008 ident: 10.1016/j.gene.2023.148016_b0220 article-title: A GPR54-activating mutation in a patient with central precocious puberty publication-title: N. Engl. J. Med. doi: 10.1056/NEJMoa073443 contributor: fullname: Teles |
SSID | ssj0000552 |
Score | 2.4882686 |
Snippet | [Display omitted]
•Elevated levels of Kp-10, NKB and NPY in a girl with idiopathic central precocious puberty.•Reduction in the levels of the neuropeptides... Understanding the pathophysiology of idiopathic central precocious puberty (ICPP) is essential, in view of its consequences on reproductive health and... |
SourceID | proquest crossref elsevier |
SourceType | Aggregation Database Publisher |
StartPage | 148016 |
SubjectTerms | Central precocious puberty Kisspeptin Neurokinin B Neuropeptide Y Nonsynonymous variant |
Title | Relevance of augmented kisspeptin signaling through H364 KISS1R in central precocious puberty |
URI | https://dx.doi.org/10.1016/j.gene.2023.148016 https://search.proquest.com/docview/2892012334 |
Volume | 895 |
hasFullText | 1 |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3NS8MwFA9jIuhBdCrOLyKIF6lrm6ZtjnM4Noc7OAdeJCRNKhPsim4HL_7tvtcP_AA9eGtLGsr7JS_v1_zeCyGngqtIeWnqCJsKIChGOEL42uFuaIpURlWIMW_G4WAaXN_z-wbp1bkwKKusfH_p0wtvXT3pVNbs5LNZZ-IyzJLECKUs044Z7LAYwZi-eP-UebiclzsJyJagdZU4U2q8ACMslekzcBjgqsPfFqcfbrpYe_qbZKMKGmm3_K4t0rBZi2x3MyDMz2_0jBYyzuL_eIusXtZX619qDW6Th1vMJEeM6TylavlYVOM0FALI1xylLRlFLYfC9HRand5DBywM6Gg4mXi3FBpUSk6aI41OUD1LAU6szrtDpv2ru97Aqc5WcBI_ZAsntbHwjHUTpTWLuPCNcC0PDLBDncQh0Aw_1SZIIiEMj4TxmWZxrCBai7RRnst2STObZ3aP0NSySHCuY9e6QQQde1bDZI6U9W0Ys7hNzmujyrwsoSFrbdmTRAgkQiBLCNqE13aX3waCBB__53snNUgSZghue6jMgiEkUEofI0cW7P-z7wOyBncBirU9fkiai5elPYJYZKGPi8F2TFa6w9Fg_AFsAtym |
link.rule.ids | 315,786,790,4521,24144,27957,27958,45620,45714 |
linkProvider | Elsevier |
linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3BTtwwEB3RRajtoaJQVCilrlT1UkWbxHYcHxdUlGVhDyxIXCrLjh0EUsOqXQ79e2YSRy2V2gO3KImtaJ79PBO_GQN80tIqmzVNokOjMUDxOtE6d4lMC9-lMtpOjHk2L6pLcXIlr9bgaMiFIVll5P6e0zu2jnfG0Zrj5c3NeJFyypIkD6Uv0_4M1oVUmRjB-mQ6q-a_CVnKfjOBAiZsEHNnepkXwkTVMnOOnIFsXfxrffqLqbvl53gTXkW_kU36T3sNa6Hdgu1JizHz91_sM-uUnN0v8i3YOByuXv5RbnAbvp1TMjnBzO4aZu-vu4KcnqEP-XNJ6paWkZzDUoY6iwf4sIoXgs2mi0V2zvCFKOZkS4qkaxLQMkSUCvS-gcvjrxdHVRKPV0jqvOCrpAmlznxIa-scV1LnXqdBCo8BoqvLAiONvHFe1EprL5X2OXe8LC06bMp5m6V8B0btXRveAmsCV1pKV6YhFQo7zoLD-axsyENR8nIXvgxGNcu-ioYZ5GW3hiAwBIHpIdgFOdjdPBoLBmn-v-0-DiAZnCS082HbgIYwGFXm5DxysffEvj_A8-ri7NScTuezd_ACnwjSbmdyH0arH_fhPbomK3cQh94DFeTfXA |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Relevance+of+augmented+kisspeptin+signaling+through+H364+KISS1R+in+central+precocious+puberty&rft.jtitle=Gene&rft.au=Banerjee%2C+Antara+A&rft.au=Bhanarkar%2C+Shital+R&rft.au=Keshwani%2C+Rachna&rft.au=Pande%2C+Shailesh&rft.date=2024-02-15&rft.eissn=1879-0038&rft.volume=895&rft.spage=148016&rft.epage=148016&rft_id=info:doi/10.1016%2Fj.gene.2023.148016&rft.externalDBID=NO_FULL_TEXT |
thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0378-1119&client=summon |
thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0378-1119&client=summon |
thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0378-1119&client=summon |