Metformin-associated lactic acidosis may be treatable with thiamine

• Published in: Medical hypotheses Vol. 189; p. 111416
• Main Authors: Ott, Michael, Werneke, Ursula
• Format: Journal Article
• Language: English
• Published: Elsevier Ltd 01.08.2024

•Metformin and thiamine deficiency can cause lactic acidosis.•Both compete at the same hepatic transporters.•Therefore, thiamine may be a treatmentfor metformin-associated lactic acidosis. Metformin is a biguanide antidiabetic and a first-line therapy for type-2 diabetes mellitus. It is highly effec...