Diphoterine for Chemical Burns of the Skin: A Systematic Review
The incidence of chemical burns appears to be increasing. Diphoterine is an amphoteric, chelating, polyvalent solution used for the decontamination of chemical splashes. In this systematic review, we aimed to assess the effect of diphoterine on chemical burns compared with water or no treatment. The...
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Published in | European burn journal Vol. 4; no. 1; pp. 55 - 68 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
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MDPI AG
01.03.2023
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Abstract | The incidence of chemical burns appears to be increasing. Diphoterine is an amphoteric, chelating, polyvalent solution used for the decontamination of chemical splashes. In this systematic review, we aimed to assess the effect of diphoterine on chemical burns compared with water or no treatment. The primary endpoint was the depth of burn, and secondary outcomes included pain, duration of hospitalization, time to return to work, need for surgery, pH, and complications. PubMed, Embase, Cochrane Library, Web of Science, and Google Scholar were systematically searched using the terms “Diphoterine”, “Previn”, and ““Amphoteric solution” AND “burn””. A total of nine studies were included. One study evaluated the depth of chemical burns and found no difference between the diphoterine group and the control group. Four studies reported on pain, three of which found a more pronounced decrease in pain when using diphoterine compared to the control groups. Two studies found a significant neutralization of pH when using diphoterine. No differences were found for the remaining endpoints. Based on the very low certainty of evidence, this systematic review reports no observed difference between diphoterine and water or no treatment on the depth of a chemical burn. Diphoterine appeared to be associated with less pain and to have a neutralizing effect. |
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AbstractList | The incidence of chemical burns appears to be increasing. Diphoterine is an amphoteric, chelating, polyvalent solution used for the decontamination of chemical splashes. In this systematic review, we aimed to assess the effect of diphoterine on chemical burns compared with water or no treatment. The primary endpoint was the depth of burn, and secondary outcomes included pain, duration of hospitalization, time to return to work, need for surgery, pH, and complications. PubMed, Embase, Cochrane Library, Web of Science, and Google Scholar were systematically searched using the terms “Diphoterine”, “Previn”, and ““Amphoteric solution” AND “burn””. A total of nine studies were included. One study evaluated the depth of chemical burns and found no difference between the diphoterine group and the control group. Four studies reported on pain, three of which found a more pronounced decrease in pain when using diphoterine compared to the control groups. Two studies found a significant neutralization of pH when using diphoterine. No differences were found for the remaining endpoints. Based on the very low certainty of evidence, this systematic review reports no observed difference between diphoterine and water or no treatment on the depth of a chemical burn. Diphoterine appeared to be associated with less pain and to have a neutralizing effect. |
Author | Dinesen, Felicia Pape, Pernille Vestergaard, Martin Risom Rasmussen, Lars Simon |
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Cites_doi | 10.1136/bmj.n71 10.1080/15569520601013160 10.1111/iwj.13193 10.1111/j.1365-4632.2009.04397.x 10.1080/15569527.2016.1217423 10.1016/j.burns.2017.09.017 10.1186/s40360-020-00465-8 10.1016/j.burnso.2018.03.001 10.11613/BM.2012.031 10.1016/j.bjps.2017.02.013 10.1080/15569520600695520 10.1016/j.burns.2011.09.014 10.1136/bmj.b2535 10.1177/0960327115578866 10.1016/j.legalmed.2009.01.008 10.3109/15569520903269122 |
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Title | Diphoterine for Chemical Burns of the Skin: A Systematic Review |
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