The cancer genome atlas - TCGA molecular classification: A changing paradigm in the management of endometrial cancers

Conventionally, endometrial cancers have been risk-stratified as per the clinco-pathological factors. The Cancer Genome Atlas project identified four distinct molecular subtypes within endometrial cancers which further lead to the clinical validation of molecular classification by various research g...

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Published inCurrent medicine research and practice Vol. 13; no. 2; pp. 69 - 73
Main Author Modi, Rahul
Format Journal Article
LanguageEnglish
Published Wolters Kluwer India Pvt. Ltd 01.03.2023
Medknow Publications and Media Pvt. Ltd
Wolters Kluwer Medknow Publications
Subjects
Adjuvant treatment
Analysis
Cancer
Endometrial cancer
Evidence-based medicine
Genetic aspects
Genomics
Health aspects
micro-satellite instability
molecular classification
Oncology, Experimental
p53 mutation
pole mutation
p53 mutation
POLE mutation
Endometrial cancer
micro-satellite instability
molecular classification
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Abstract Conventionally, endometrial cancers have been risk-stratified as per the clinco-pathological factors. The Cancer Genome Atlas project identified four distinct molecular subtypes within endometrial cancers which further lead to the clinical validation of molecular classification by various research groups. The molecular classification has influenced the risk stratification, thereby impacting adjuvant treatment decisions and prognostication. Molecular classification has paved the precision oncology in gynaecological cancers further strengthening the ongoing advances in targeted therapies and immunotherapy. This review elaborately presents the development of a new molecular classification of endometrial cancers; its evidence-based clinical utility with a brief overview of future perspectives.
AbstractList Conventionally, endometrial cancers have been risk-stratified as per the clinco-pathological factors. The Cancer Genome Atlas project identified four distinct molecular subtypes within endometrial cancers which further lead to the clinical validation of molecular classification by various research groups. The molecular classification has influenced the risk stratification, thereby impacting adjuvant treatment decisions and prognostication. Molecular classification has paved the precision oncology in gynaecological cancers further strengthening the ongoing advances in targeted therapies and immunotherapy. This review elaborately presents the development of a new molecular classification of endometrial cancers; its evidence-based clinical utility with a brief overview of future perspectives.
Audience Academic
Author Modi, Rahul
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Keywords p53 mutation
POLE mutation
Endometrial cancer
micro-satellite instability
molecular classification
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SubjectTerms Adjuvant treatment
Analysis
Cancer
Endometrial cancer
Evidence-based medicine
Genetic aspects
Genomics
Health aspects
micro-satellite instability
molecular classification
Oncology, Experimental
p53 mutation
pole mutation
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Title The cancer genome atlas - TCGA molecular classification: A changing paradigm in the management of endometrial cancers
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