Changes of Expression of Stretch-activated Potassium Channel TREK-1 mRNA and Protein in Hypertrophic Myocardium

• Published in: Journal of Huazhong University of Science and Technology. Medical sciences Vol. 26; no. 1; pp. 31 - 33
• Main Author: 程龙献 苏方成 瑞奔曾哥 樊红 黄恺 王敏 彭红玉 梅春丽 赵芳 廖玉华
• Format: Journal Article
• Language: English
• Published: China Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022 , China 2006
• Subjects: Animals; Aorta, Abdominal; Constriction; Hypertrophy; Hypertrophy, Left Ventricular - etiology; Hypertrophy, Left Ventricular - metabolism; Male; mRNA; Myocardium - metabolism; Myocardium - pathology; Potassium Channels, Tandem Pore Domain - biosynthesis; Potassium Channels, Tandem Pore Domain - genetics; Proteins - metabolism; Random Allocation; Rats; Rats, Wistar; RNA, Messenger - biosynthesis; RNA, Messenger - genetics; Up-Regulation; Ventricular Remodeling; 心肌细胞; 病理机制; 钾元素; ventricular remodeling; stretch-activated potassium channel; electrical remodeling; hypertrophic myocardium

The expression of stretch activated potassium channel TREK-1 mRNA and protein of hypertrophic myocardium was measured. Using a model of hypertrophy induced by coarctation of abdominal aorta in male Wistar rats, the expression of TREK-1 mRNA and protein was detected by using semi quantitative RT-PCR...