Straightforward synthesis of the pentasaccharide repeating unit of the cell wall O-antigen of Escherichia coli O43 strain

A concise synthetic strategy has been developed for the synthesis of the pentasaccharide repeating unit of the cell wall O -antigen of Escherichia coli O43 strain involving stereoselective β-D-mannosylation and α-L-fucosylation using corresponding trichloroacetimidate intermediates and perchloric ac...

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Bibliographic Details
Published inGlycoconjugate journal Vol. 37; no. 5; pp. 647 - 656
Main Authors Shit, Pradip, Misra, Anup Kumar
Format Journal Article
LanguageEnglish
Published New York Springer US 01.10.2020
Subjects
Biochemistry
Biomedical and Life Sciences
Life Sciences
Original Article
Pathology
Diarrhea
Glycosylation
antigen
Oligosaccharide
O-antigen
E. coli
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Summary:A concise synthetic strategy has been developed for the synthesis of the pentasaccharide repeating unit of the cell wall O -antigen of Escherichia coli O43 strain involving stereoselective β-D-mannosylation and α-L-fucosylation using corresponding trichloroacetimidate intermediates and perchloric acid supported over silica (HClO 4 -SiO 2 ) as glycosylation promoter. The yield and stereoselectivity of the glycosylations were very good.
Bibliography:ObjectType-Article-1
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ISSN:0282-0080
1573-4986
1573-4986
DOI:10.1007/s10719-020-09933-z