The Post-conditioning Acute Strength Exercise Facilitates Contextual Fear Memory Consolidation Via Hippocampal N-methyl-D-aspartate-receptors

The benefits of aerobic exercises for memory are known, but studies of strength training on memory consolidation are still scarce. Exercise stimulates the release of metabolites and myokines that reaching the brain stimulate the activation of NMDA-receptors and associated pathways related to cogniti...

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Published inNeuroscience Vol. 535; pp. 88 - 98
Main Authors Leite, Ana Karla Oliveira, Farias, Clarissa Penha, Schmidt, Bianca Estefani, Teixeira, Lucas, Rieder, Alessandra Schmitt, Furini, Cristiane R G, Wyse, Angela T S
Format Journal Article
LanguageEnglish
Published United States 15.12.2023
Subjects
Animals
Brain-Derived Neurotrophic Factor - metabolism
Dizocilpine Maleate - pharmacology
Fear - physiology
Hippocampus - metabolism
Male
Memory Consolidation - physiology
N-Methylaspartate - metabolism
Rats
Rats, Wistar
Receptors, N-Methyl-D-Aspartate - metabolism
Synapsins - metabolism
strength training
consolidation processes
hippocampus
fear memory
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Abstract The benefits of aerobic exercises for memory are known, but studies of strength training on memory consolidation are still scarce. Exercise stimulates the release of metabolites and myokines that reaching the brain stimulate the activation of NMDA-receptors and associated pathways related to cognition and synaptic plasticity. The aim of the present study was to investigate whether the acute strength exercise could promote the consolidation of a weak memory. We also investigated whether the effects of strength exercise on memory consolidation and on the BDNF and synapsin I levels depends on the activation of NMDA-receptors. Male Wistar rats were submitted to strength exercise session after a weak training in contextual fear conditioning paradigm to investigate the induction of memory consolidation. To investigate the participation of NMDA-receptors animals were submitted to contextual fear training and strength exercise and infused with MK801 or saline immediately after exercise. To investigate the participation of NMDA-receptors in BDNF and synapsin I levels the animals were submitted to acute strength exercise and infused with MK801 or saline immediately after exercise (in absence of behavior experiment). Results showed that exercise induced the consolidation of a weak memory and this effect was dependent on the activation of NMDA-receptors. The hippocampal overexpression of BDNF and Synapsin I through exercise where NMDA-receptors dependent. Our findings showed that strength exercise strengthened fear memory consolidation and modulates the overexpression of BDNF and synapsin I through the activation of NMDA-receptors dependent signaling pathways.
AbstractList The benefits of aerobic exercises for memory are known, but studies of strength training on memory consolidation are still scarce. Exercise stimulates the release of metabolites and myokines that reaching the brain stimulate the activation of NMDA-receptors and associated pathways related to cognition and synaptic plasticity. The aim of the present study was to investigate whether the acute strength exercise could promote the consolidation of a weak memory. We also investigated whether the effects of strength exercise on memory consolidation and on the BDNF and synapsin I levels depends on the activation of NMDA-receptors. Male Wistar rats were submitted to strength exercise session after a weak training in contextual fear conditioning paradigm to investigate the induction of memory consolidation. To investigate the participation of NMDA-receptors animals were submitted to contextual fear training and strength exercise and infused with MK801 or saline immediately after exercise. To investigate the participation of NMDA-receptors in BDNF and synapsin I levels the animals were submitted to acute strength exercise and infused with MK801 or saline immediately after exercise (in absence of behavior experiment). Results showed that exercise induced the consolidation of a weak memory and this effect was dependent on the activation of NMDA-receptors. The hippocampal overexpression of BDNF and Synapsin I through exercise where NMDA-receptors dependent. Our findings showed that strength exercise strengthened fear memory consolidation and modulates the overexpression of BDNF and synapsin I through the activation of NMDA-receptors dependent signaling pathways.
Author Furini, Cristiane R G
Rieder, Alessandra Schmitt
Farias, Clarissa Penha
Wyse, Angela T S
Leite, Ana Karla Oliveira
Schmidt, Bianca Estefani
Teixeira, Lucas
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  givenname: Angela T S
  surname: Wyse
  fullname: Wyse, Angela T S
  email: wyse@ufrgs.br
  organization: Postgraduate Program in Translational Neuroscience, PGNET, National Institute of Translational Neuroscience, Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, RJ, Brazil; Neuroprotection and Neurometabolic Diseases Laboratory (Wyse's Lab), Graduate Program in Biological Sciences: Biochemistry, Department of Biochemistry, ICBS, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil. Electronic address: wyse@ufrgs.br
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Keywords strength training
consolidation processes
hippocampus
fear memory
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Snippet The benefits of aerobic exercises for memory are known, but studies of strength training on memory consolidation are still scarce. Exercise stimulates the...
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SubjectTerms Animals
Brain-Derived Neurotrophic Factor - metabolism
Dizocilpine Maleate - pharmacology
Fear - physiology
Hippocampus - metabolism
Male
Memory Consolidation - physiology
N-Methylaspartate - metabolism
Rats
Rats, Wistar
Receptors, N-Methyl-D-Aspartate - metabolism
Synapsins - metabolism
Title The Post-conditioning Acute Strength Exercise Facilitates Contextual Fear Memory Consolidation Via Hippocampal N-methyl-D-aspartate-receptors
URI https://www.ncbi.nlm.nih.gov/pubmed/37925051
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