CSN6 promotes malignant progression of oral squamous cell carcinoma by down-regulating TIMP-2

• Published in: European review for medical and pharmacological sciences Vol. 24; no. 10; p. 5419
• Main Authors: Gao, W-Y, Yang, G, Wang, J, He, J-M, Wang, P
• Format: Journal Article
• Language: English
• Published: Italy 01.05.2020
• Subjects: Adaptor Proteins, Signal Transducing - genetics; Adaptor Proteins, Signal Transducing - metabolism; Carcinoma, Squamous Cell - metabolism; Carcinoma, Squamous Cell - pathology; Cells, Cultured; COP9 Signalosome Complex - genetics; COP9 Signalosome Complex - metabolism; Disease Progression; Down-Regulation; Female; Gene Expression Regulation, Neoplastic; Humans; Male; Middle Aged; Mouth Neoplasms - metabolism; Mouth Neoplasms - pathology; Tissue Inhibitor of Metalloproteinase-2 - genetics; Tissue Inhibitor of Metalloproteinase-2 - metabolism

This study was designed to investigate the expression characteristics of CSN6 in oral squamous cell carcinoma (OSCC), and to further explore the mechanism of how it promotes the malignant progression of this cancer. The expressions of CSN6 and TIMP-2 in tumor tissue samples and adjacent normal ones...