A systematic review on the efficacy and safety of IL-6 modulatory drugs in the treatment of COVID-19 patients
The pandemic caused by the new SARS-CoV2 coronavirus has led to an effort to find treatments that are effective against this disease that the World Health Organization calls COVID-19. In severe cases of COVID-19, there is an increase in cytokines, among which IL-6 seems to play an important role. A...
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Published in | European review for medical and pharmacological sciences Vol. 24; no. 13; p. 7475 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
Italy
01.07.2020
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Abstract | The pandemic caused by the new SARS-CoV2 coronavirus has led to an effort to find treatments that are effective against this disease that the World Health Organization calls COVID-19. In severe cases of COVID-19, there is an increase in cytokines, among which IL-6 seems to play an important role. A search has been performed for studies using IL-6 blocking drugs (tocilizumab, siltuximab, and sarilumab) in PubMed, Web of Science, and Scopus. Also, a search of ongoing trials registered at clinicaltrials.gov was performed. We found very little published clinical experience with these drugs, consisting mainly of case reports or case series with few patients. The results of clinical trials are necessary to clarify the role of these drugs in patients with COVID-19. |
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AbstractList | The pandemic caused by the new SARS-CoV2 coronavirus has led to an effort to find treatments that are effective against this disease that the World Health Organization calls COVID-19. In severe cases of COVID-19, there is an increase in cytokines, among which IL-6 seems to play an important role. A search has been performed for studies using IL-6 blocking drugs (tocilizumab, siltuximab, and sarilumab) in PubMed, Web of Science, and Scopus. Also, a search of ongoing trials registered at clinicaltrials.gov was performed. We found very little published clinical experience with these drugs, consisting mainly of case reports or case series with few patients. The results of clinical trials are necessary to clarify the role of these drugs in patients with COVID-19. |
Author | Jordán, J Galindo, M F Solis-García Del Pozo, J Nava, E |
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SubjectTerms | Antibodies, Monoclonal - pharmacology Antibodies, Monoclonal, Humanized - pharmacology Antiviral Agents - pharmacology Betacoronavirus - drug effects Betacoronavirus - immunology Coronavirus Infections - diagnosis Coronavirus Infections - drug therapy Coronavirus Infections - immunology COVID-19 Humans Interleukin-6 - antagonists & inhibitors Interleukin-6 - immunology Pandemics - prevention & control Pneumonia, Viral - diagnosis Pneumonia, Viral - drug therapy Pneumonia, Viral - immunology SARS-CoV-2 |
Title | A systematic review on the efficacy and safety of IL-6 modulatory drugs in the treatment of COVID-19 patients |
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