Comparison of early wound healing using modified papilla preservation technique between enamel matrix derivative and recombinant human fibroblast growth factor

• Published in: Journal of periodontal & implant science Vol. 54; no. 4; pp. 236 - 252
• Main Authors: Nakayama, Yohei, Tabe, Shinichi, Igarashi, Kazuma, Moriya, Satoshi, Katsumata, Tsuyoshi, Kobayashi, Ryo, Nakagawa, Shuta, Nishino, Tomoko, Fukuoka, Namiko, Hosono, Kota, Yamasaki, Mai, Yamazaki, Yosuke, Ogihara-Takeda, Moe, Ito, Shoichi, Saito, Yumi, Yamaguchi, Arisa, Tsuruya, Yuto, Yamazaki-Takai, Mizuho, Yoshino, Shoichi, Takai, Hideki, Ogata, Yorimasa
• Format: Journal Article
• Language: English
• Published: Korea (South) 대한치주과학회 01.08.2024
• Subjects: 치의학; Fibroblast growth factor 2; Inflammation; Wound healing
• DOI: 10.5051/jpis.2303080154
• ISSN: 2093-2278

Enamel matrix derivative (EMD) has demonstrated beneficial effects on wound healing following surgery. However, the effects of recombinant human fibroblast growth factor 2 (rhFGF-2) in periodontal regeneration therapy have not been extensively studied. This retrospective study was conducted to compare the wound healing outcomes of the modified papilla preservation technique (mPPT) between EMD and rhFGF-2 therapies. A total of 79 sites were evaluated for early wound healing using the modified early wound healing index (mEHI), which included 6 items: incision, fibrin clotting, step, redness, swelling, and dehiscence. A numeric analog scale, along with postoperative images of the 6 mEHI items, was established and used for the evaluations. The inter-rater reliability of the mEHI was assessed via intraclass correlation coefficients (ICCs). After adjusting for factors influencing the mPPT, the differences in mEHI scores between the EMD and rhFGF-2 groups were statistically analyzed. Additionally, radiographic bone fill (RBF) was evaluated 6 months after surgery. The ICC of the mEHI was 0.575. The mEHI, redness score, and dehiscence scores were significantly higher in the rhFGF-2 group (n=33) than in the EMD group (n=46). Similar results were observed in the subgroup of patients aged 50 years or older, but not in those younger than 50 years. In the subgroup with non-contained bone defects, related results were noted, but not in the subgroup with contained bone defects. However, early wound healing did not correlate with RBF at 6 months after surgery. Within the limitations of this study, the findings suggest that early wound healing following the use of mPPT with rhFGF-2 is somewhat superior to that observed after mPPT with EMD. However, mEHI should be improved for use as a predictive tool for early wound healing and to reflect clinical outcomes after surgery.