Mutagenic, surviving and tumorigenic effects of follicular fluid in the context of p53 loss: initiation of fimbria carcinogenesis

• Published in: Carcinogenesis (New York) Vol. 36; no. 11; pp. 1419 - 1428
• Main Authors: Huang, Hsuan-Shun, Chu, Sung-Chao, Hsu, Che-Fang, Chen, Pao-Chu, Ding, Dah-Ching, Chang, Meng-Ya, Chu, Tang-Yuan
• Format: Journal Article
• Language: English
• Published: England 01.11.2015
• Subjects: Adult; Animals; Carcinogenesis - genetics; Carcinogenesis - metabolism; Cell Survival; DNA Breaks, Double-Stranded; Epithelium - pathology; Fallopian Tubes - pathology; Female; Follicular Fluid - physiology; Humans; Mice, Inbred C57BL; Mice, Knockout; Middle Aged; Mutagenesis; Neoplasms, Glandular and Epithelial - genetics; Neoplasms, Glandular and Epithelial - metabolism; Neoplasms, Glandular and Epithelial - pathology; Ovarian Neoplasms - genetics; Ovarian Neoplasms - metabolism; Ovarian Neoplasms - pathology; Reactive Oxygen Species - metabolism; Tumor Cells, Cultured; Tumor Suppressor Protein p53 - genetics

Ovulation is the strongest risk factor for ovarian high-grade serous carcinoma (HGSC) that largely originates from the fallopian tube fimbriae and always carries loss-of-function mutations of TP53 in both early and late lesions. Mature ovarian follicle contains high level of reactive oxygen species...