Distribution of substance P in the human liver-light and electron microscopic study by the immunohistochemical techniques
Light and electron microscopic immunohistochemical techniques were used to examine the distribution and ultrastructure of substance P-containing nerves in the human liver. On the light microscopy, substance P-containing nerve fibers were present around the portal vein, bile duct and hepatic artery,...
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| Published in | Kanzo Vol. 29; no. 3; pp. 358 - 364 |
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| Main Authors | , , , , , , , , |
| Format | Journal Article |
| Language | Japanese |
| Published |
The Japan Society of Hepatology
1988
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| Subjects | |
| Online Access | Get full text |
| ISSN | 0451-4203 1881-3593 |
| DOI | 10.2957/kanzo.29.358 |
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| Abstract | Light and electron microscopic immunohistochemical techniques were used to examine the distribution and ultrastructure of substance P-containing nerves in the human liver. On the light microscopy, substance P-containing nerve fibers were present around the portal vein, bile duct and hepatic artery, along the sinusoid and hepatocytes, and around the central vein. On the electron microscopy, substance P-containing nerve endings which contain small and large round vesicles were present close to the fibroblast, Ito cell, Myofibroblast and endothelial cell around the portal vein, sinusoid and central vein. Moreover, substance P-containing nerve cell bodies were observed in the portal area, Disse's space and connective tissue around the central vein. These results suggest that substance P-containing nerves may play important roles in the contraction of the fibroblast, Ito cell, myofibroblast and endothelial cell, and in the regulation of hepatic hemodynamics. |
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| AbstractList | Light and electron microscopic immunohistochemical techniques were used to examine the distribution and ultrastructure of substance P-containing nerves in the human liver. On the light microscopy, substance P-containing nerve fibers were present around the portal vein, bile duct and hepatic artery, along the sinusoid and hepatocytes, and around the central vein. On the electron microscopy, substance P-containing nerve endings which contain small and large round vesicles were present close to the fibroblast, Ito cell, Myofibroblast and endothelial cell around the portal vein, sinusoid and central vein. Moreover, substance P-containing nerve cell bodies were observed in the portal area, Disse's space and connective tissue around the central vein. These results suggest that substance P-containing nerves may play important roles in the contraction of the fibroblast, Ito cell, myofibroblast and endothelial cell, and in the regulation of hepatic hemodynamics. |
| Author | ABE, Hirohiko INUZUKA, Sadataka NOGUCHI, Kazunori TANIKAWA, Kyuichi YOSHITAKE, Masao UENO, Takato TORIMURA, Takuji SHAKADO, Satoshi SIBMOTSUURA, Yasuhiro |
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| References | 17) 上野隆登,犬塚貞孝,鳥村拓司,他:過栄養性脂肪肝におけるMyofibroblast, Fat-storing cell (Ito cell)の電顕的観察.肝臓28: 1040-1046, 1987 1) Ito T, Shibasaki S: Electron microscopic study on the hepatic sinusoidal wall and the fat-storing cells in the norrnal human liver. Arch Histol Jap 29: 137-192, 1968 12) Brodin E, Sjolund K, Hakanson R: Substance P-containing nerve fibers are numerous in human but not in feline intestinal mucosa. Gastroenterology 85: 557-564, 1983 3) Tanikawa K: The nervous system in the normal liver. In: Ultrastructural aspects of the liver and its disorder, Edited by K Tanikawa, Igaku-Shoin, Tokyo, New York, 1979, p70-74 6) Takano Y, nagashima A, Masui H: Distribution of substance K (neurokinin A) in the brain and perioheral tissues of rats. Brain Res 369: 400-404, 1986 15) Joyce NC, Haire MF, Palade GE: Morphologic and biochemical evidence for a contractile cell network within the rat intestinal mucosa. Gastroenterology 92: 68-81, 1987 7) Fridman MI: Hepatic nerve function. In: The Liver. Biology and Phathology, Edited by Arias I, Popper H, Shachter D. Raven Press, New York, 1982, p663-673 13) Llewellyn-Smith IJ, Fumess JB, Murphy R: Substance P-containing nerves in the human small intestine. Gastroenterology 86: 421-435, 1984 18) Barja F, Mathison R: Adrenrgic and peptidergic (substance P and vasoactive intestinal polypeptide) innervation of the rat portal vein. Blood V essels 19: 263-272, 1982 8) Gabell G: Innervation of the gastrointestinal tract. Int Rev Cytol 59: 129-193, 1979 4) 上野隆登,権藤和久,吉武正男,他:肝内神経分布に関する電顕的観察.肝臓28 (5): 586-592, 1987 16) Sasaki Y, kamada T, Hayashi N: Immunohistochemical distribution of glucagon, substance P and vasoactive intestinal polypeptide in hepatic vasculature of the rat. Hepatology 4: 1184-1189, 1984 10) Irwin DA: The anatomy of Auerbach's plexus. Am J Anat 49: 141-166, 1931 11) Christensen J, Rick GA: Nerve cell density in submucous plexus throughout the gut of cat and orossum. Gastroenterology 89: 1064-1069, 1985 9) 小室輝昌,上原康生:消化管平滑筋の構造と機能の基礎-A.筋と神経の微細構造「消化管運動機能調節剤」.医薬ジャーナル,大阪,1985, p19-41 2) Forssmann WG, Ito S: Hepatic innervation in primates. J Cell Biol 73: 299-313, 1977 5) Pernow B: Substance P. Phamlacol Rev 35(2): 85-141, 1983 14) Yau WM: Effect of substance P on intestinal muscle. Gastroenterology 74: 228-231, 1978 |
| References_xml | – reference: 3) Tanikawa K: The nervous system in the normal liver. In: Ultrastructural aspects of the liver and its disorder, Edited by K Tanikawa, Igaku-Shoin, Tokyo, New York, 1979, p70-74 – reference: 4) 上野隆登,権藤和久,吉武正男,他:肝内神経分布に関する電顕的観察.肝臓28 (5): 586-592, 1987 – reference: 11) Christensen J, Rick GA: Nerve cell density in submucous plexus throughout the gut of cat and orossum. Gastroenterology 89: 1064-1069, 1985 – reference: 9) 小室輝昌,上原康生:消化管平滑筋の構造と機能の基礎-A.筋と神経の微細構造「消化管運動機能調節剤」.医薬ジャーナル,大阪,1985, p19-41 – reference: 12) Brodin E, Sjolund K, Hakanson R: Substance P-containing nerve fibers are numerous in human but not in feline intestinal mucosa. Gastroenterology 85: 557-564, 1983 – reference: 5) Pernow B: Substance P. Phamlacol Rev 35(2): 85-141, 1983 – reference: 16) Sasaki Y, kamada T, Hayashi N: Immunohistochemical distribution of glucagon, substance P and vasoactive intestinal polypeptide in hepatic vasculature of the rat. Hepatology 4: 1184-1189, 1984 – reference: 6) Takano Y, nagashima A, Masui H: Distribution of substance K (neurokinin A) in the brain and perioheral tissues of rats. Brain Res 369: 400-404, 1986 – reference: 15) Joyce NC, Haire MF, Palade GE: Morphologic and biochemical evidence for a contractile cell network within the rat intestinal mucosa. Gastroenterology 92: 68-81, 1987 – reference: 17) 上野隆登,犬塚貞孝,鳥村拓司,他:過栄養性脂肪肝におけるMyofibroblast, Fat-storing cell (Ito cell)の電顕的観察.肝臓28: 1040-1046, 1987 – reference: 8) Gabell G: Innervation of the gastrointestinal tract. Int Rev Cytol 59: 129-193, 1979 – reference: 10) Irwin DA: The anatomy of Auerbach's plexus. Am J Anat 49: 141-166, 1931 – reference: 7) Fridman MI: Hepatic nerve function. In: The Liver. Biology and Phathology, Edited by Arias I, Popper H, Shachter D. Raven Press, New York, 1982, p663-673 – reference: 14) Yau WM: Effect of substance P on intestinal muscle. Gastroenterology 74: 228-231, 1978 – reference: 2) Forssmann WG, Ito S: Hepatic innervation in primates. J Cell Biol 73: 299-313, 1977 – reference: 13) Llewellyn-Smith IJ, Fumess JB, Murphy R: Substance P-containing nerves in the human small intestine. Gastroenterology 86: 421-435, 1984 – reference: 1) Ito T, Shibasaki S: Electron microscopic study on the hepatic sinusoidal wall and the fat-storing cells in the norrnal human liver. Arch Histol Jap 29: 137-192, 1968 – reference: 18) Barja F, Mathison R: Adrenrgic and peptidergic (substance P and vasoactive intestinal polypeptide) innervation of the rat portal vein. Blood V essels 19: 263-272, 1982 |
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| Title | Distribution of substance P in the human liver-light and electron microscopic study by the immunohistochemical techniques |
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