In-Vitro and In-Vivo Electrical Characteristics of a Penetrating Microelectrode Array for Optic Nerve Electrical Stimulation
The Chinese C-Sight team aims to restore vision to blind patients by means of stimulating the optic nerve with a penetrating microelectrode array. A biocompatible, implantable microwire array was developed having four platinum-iridium shafts, each 100μm in diameter. This penetrating microwire array...
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| Published in | Shanghai jiao tong da xue xue bao Vol. 16; no. 5; pp. 614 - 619 |
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| Main Author | |
| Format | Journal Article |
| Language | English |
| Published |
Heidelberg
Shanghai Jiaotong University Press
01.10.2011
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| Subjects | |
| Online Access | Get full text |
| ISSN | 1007-1172 1995-8188 |
| DOI | 10.1007/s12204-011-1198-0 |
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| Abstract | The Chinese C-Sight team aims to restore vision to blind patients by means of stimulating the optic nerve with a penetrating microelectrode array. A biocompatible, implantable microwire array was developed having four platinum-iridium shafts, each 100μm in diameter. This penetrating microwire array is described in this paper, including its fabrication techniques and its in-vitro electrical characteristics. Every set of four shafts was spaced 0.4mm from center to center, comprising two short shafts that were 0.3mm long and two that were 0.9mm long. This design was intended to stimulate ganglion cell axons at different depths within the optic nerve. In-vitro electrochemical impedance testing results showed that the impedance at 1kHz ranged from 8 to 10kΩ at room temperature. The voltage responses of the arrays to current pulse stimulation indicated a charge-injection capacity of 210μC/cm2. Finally, in-vivo acute animal experiments showed that the amplitude of the electrically evoked potentials （EEPs） measured in primary visual cortex could be as large as 100 μV upon direct stimulation of the optic nerve. |
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| AbstractList | The Chinese C-Sight team aims to restore vision to blind patients by means of stimulating the optic nerve with a penetrating microelectrode array. A biocompatible, implantable microwire array was developed having four platinum-iridium shafts, each 100μm in diameter. This penetrating microwire array is described in this paper, including its fabrication techniques and its in-vitro electrical characteristics. Every set of four shafts was spaced 0.4mm from center to center, comprising two short shafts that were 0.3mm long and two that were 0.9mm long. This design was intended to stimulate ganglion cell axons at different depths within the optic nerve. In-vitro electrochemical impedance testing results showed that the impedance at 1kHz ranged from 8 to 10kΩ at room temperature. The voltage responses of the arrays to current pulse stimulation indicated a charge-injection capacity of 210μC/cm2. Finally, in-vivo acute animal experiments showed that the amplitude of the electrically evoked potentials （EEPs） measured in primary visual cortex could be as large as 100 μV upon direct stimulation of the optic nerve. The Chinese C-Sight team aims to restore vision to blind patients by means of stimulating the optic nerve with a penetrating microelectrode array. A biocompatible, implantable microwire array was developed having four platinum-iridium shafts, each 100 mu m in diameter. This penetrating microwire array is described in this paper, including its fabrication techniques and its in-vitro electrical characteristics. Every set of four shafts was spaced 0.4 mm from center to center, comprising two short shafts that were 0.3 mm long and two that were 0.9 mm long. This design was intended to stimulate ganglion cell axons at different depths within the optic nerve. In-vitro electrochemical impedance testing results showed that the impedance at 1kHz ranged from 8 to 10k Omega at room temperature. The voltage responses of the arrays to current pulse stimulation indicated a charge-injection capacity of 210 mu C/cm(2). Finally, in-vivo acute animal experiments showed that the amplitude of the electrically evoked potentials (EEPs) measured in primary visual cortex could be as large as 100 mu V upon direct stimulation of the optic nerve. The Chinese C-Sight team aims to restore vision to blind patients by means of stimulating the optic nerve with a penetrating microelectrode array. A biocompatible, implantable microwire array was developed having four platinum-iridium shafts, each 100 μm in diameter. This penetrating microwire array is described in this paper, including its fabrication techniques and its in-vitro electrical characteristics. Every set of four shafts was spaced 0.4mm from center to center, comprising two short shafts that were 0.3mm long and two that were 0.9mm long. This design was intended to stimulate ganglion cell axons at different depths within the optic nerve. In-vitro electrochemical impedance testing results showed that the impedance at 1 kHz ranged from 8 to 10 kΩ at room temperature. The voltage responses of the arrays to current pulse stimulation indicated a charge-injection capacity of 210 μC/cm 2 . Finally, in-vivo acute animal experiments showed that the amplitude of the electrically evoked potentials (EEPs) measured in primary visual cortex could be as large as 100 μV upon direct stimulation of the optic nerve. |
| Author | 隋晓红 邵轶彬 李丽明 柴新禹 任秋实 |
| AuthorAffiliation | Institute of Laser Medicine and Biophotonics, Shanghai Jiaotong Universtiy;Department of Biomedical Engineering, Peking University |
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| Cites_doi | 10.1111/j.1749-6632.1983.tb31628.x 10.1016/j.jneumeth.2004.10.020 10.1016/S1388-2457(99)00027-9 10.1007/BF02738534 10.1167/iovs.02-0819 10.1007/s00417-004-0957-0 10.1109/TBME.2002.805487 10.1007/s10384-004-0055-1 10.1016/S0304-3940(97)00185-7 10.1159/000268025 10.1007/s004170050358 10.1046/j.1525-1594.2003.07308.x 10.1016/j.ssi.2004.12.016 10.1016/S0006-8993(98)00977-9 10.1088/1741-2560/2/1/004 10.1016/S0042-6989(03)00457-7 10.1113/jphysiol.1974.sp010766 |
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| Notes | 31-1943/U The Chinese C-Sight team aims to restore vision to blind patients by means of stimulating the optic nerve with a penetrating microelectrode array. A biocompatible, implantable microwire array was developed having four platinum-iridium shafts, each 100μm in diameter. This penetrating microwire array is described in this paper, including its fabrication techniques and its in-vitro electrical characteristics. Every set of four shafts was spaced 0.4mm from center to center, comprising two short shafts that were 0.3mm long and two that were 0.9mm long. This design was intended to stimulate ganglion cell axons at different depths within the optic nerve. In-vitro electrochemical impedance testing results showed that the impedance at 1kHz ranged from 8 to 10kΩ at room temperature. The voltage responses of the arrays to current pulse stimulation indicated a charge-injection capacity of 210μC/cm2. Finally, in-vivo acute animal experiments showed that the amplitude of the electrically evoked potentials （EEPs） measured in primary visual cortex could be as large as 100 μV upon direct stimulation of the optic nerve. optic nerve visual prosthesis, platinum-iridium （Pt/Ir） microelectrode, charge injection capacity, impedance ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 |
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1198_CR7 publication-title: Brain Research doi: 10.1016/S0006-8993(98)00977-9 – volume: 243 start-page: 49 issue: 1 year: 2005 ident: 1198_CR10 publication-title: Graefe’s Archive for Clinical and Experimental Ophthalmology doi: 10.1007/s00417-004-0957-0 – volume: 48 start-page: 256 issue: 3 year: 2004 ident: 1198_CR9 publication-title: Japanese Journal of Ophthalmology doi: 10.1007/s10384-004-0055-1 – volume: 238 start-page: 315 issue: 4 year: 2000 ident: 1198_CR16 publication-title: Graefe’s Archive for Clinical and Experimental Ophthalmology doi: 10.1007/s004170050358 – volume: 25 start-page: 1 issue: 1 year: 1997 ident: 1198_CR14 publication-title: Annals of Biomedical Engineering doi: 10.1007/BF02738534 – volume: 225 start-page: 13 issue: 1 year: 1997 ident: 1198_CR3 publication-title: Neuroscience Letter doi: 10.1016/S0304-3940(97)00185-7 – volume: 176 start-page: 2031 issue: 25–28 year: 2005 ident: 1198_CR12 publication-title: Solid State Ionics doi: 10.1016/j.ssi.2004.12.016 – volume: 29 start-page: 269 issue: 5 year: 1997 ident: 1198_CR4 publication-title: Ophthalmic Research doi: 10.1159/000268025 – volume: 7 start-page: 361 issue: 1 year: 2005 ident: 1198_CR11 publication-title: Biomedical Engineering – volume: 243 start-page: 49 issue: 1 year: 2005 ident: 1198_CR18 publication-title: Graefe’s Archive for Clinical and Experimental Ophthalmology doi: 10.1007/s00417-004-0957-0 – volume: 43 start-page: 2573 issue: 24 year: 2003 ident: 1198_CR5 publication-title: Vision Research doi: 10.1016/S0042-6989(03)00457-7 – volume: 405 start-page: 159 issue: 1 year: 1983 ident: 1198_CR19 publication-title: Annals of the New York Academy of Sciences doi: 10.1111/j.1749-6632.1983.tb31628.x – volume: 49 start-page: 1574 issue: 12 year: 2002 ident: 1198_CR15 publication-title: IEEE Transations on Biomedical Engineering doi: 10.1109/TBME.2002.805487 |
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