Vascular Inflammation and Smooth Muscle Contractility: The Role of Nox1-Derived Superoxide and LRRC8 Anion Channels

• Published in: Hypertension (Dallas, Tex. 1979) Vol. 81; no. 4; pp. 752 - 763
• Main Authors: Lamb, Fred S, Choi, Hyehun, Miller, Michael R, Stark, Ryan J
• Format: Journal Article
• Language: English
• Published: United States 01.04.2024
• Subjects: blood pressure; NADPH oxidases; inflammation; blood vessels; rho-associated kinases; hypertension; superoxides

Vascular inflammation underlies the development of hypertension, and the mechanisms by which it increases blood pressure remain the topic of intense investigation. Proinflammatory factors including glucose, salt, vasoconstrictors, cytokines, wall stress, and growth factors enhance contractility and...