Water deprivation upregulates ANG II AT1 binding and mRNA in rat subfornical organ and anterior pituitary

• Published in: The American journal of physiology Vol. 273; no. 1 Pt 1; p. E156
• Main Authors: Sanvitto, G L, Jöhren, O, Häuser, W, Saavedra, J M
• Format: Journal Article
• Language: English
• Published: United States 01.07.1997
• Subjects: Animals; Body Weight; In Situ Hybridization; Male; Pituitary Gland, Anterior - metabolism; Protein Biosynthesis; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin - biosynthesis; RNA, Messenger - biosynthesis; Subfornical Organ - metabolism; Time Factors; Transcription, Genetic; Up-Regulation; Water Deprivation - physiology

We studied angiotensin II (ANG II) receptor subtype expression in selected brain nuclei and pituitary gland after water deprivation by in vitro receptor autoradiography using 125I-labeled [Sar1]ANG II and by in situ hybridization using 35S-labeled AT1A, AT1B, and AT2 receptor-specific riboprobes. In...