In Vitro and in Vivo Evidence for a Lack of Interaction with Dopamine D2 Receptors by the Metabotropic Glutamate 2/3 Receptor Agonists 1S,2S,5R,6S-2-Aminobicyclo[3.1.0]hexane-2,6-bicaroxylate Monohydrate (LY354740) and (−)-2-Oxa-4-aminobicyclo[3.1.0] Hexane-4,6-dicarboxylic Acid (LY379268)

• Published in: The Journal of pharmacology and experimental therapeutics Vol. 331; no. 3; pp. 1126 - 1136
• Main Authors: Fell, Matthew J., Perry, Kenneth W., Falcone, Julie F., Johnson, Bryan G., Barth, Vanessa N., Rash, Karen S., Lucaites, Virginia L., Threlkeld, Penny G., Monn, James A., McKinzie, David L., Marek, Gerard J., Svensson, Kjell A., Nelson, David L.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.12.2009; American Society for Pharmacology and Experimental Therapeutics
• Subjects: Amino Acids - pharmacology; Animals; Binding, Competitive; Bridged Bicyclo Compounds - pharmacology; Bridged Bicyclo Compounds, Heterocyclic - pharmacology; Cell Membrane - drug effects; Cell Membrane - metabolism; CHO Cells; Cricetinae; Cricetulus; Domperidone - pharmacology; Dopamine - biosynthesis; Dopamine D2 Receptor Antagonists; Female; Humans; Male; Mice; Mice, Knockout; Motor Activity - drug effects; Protein Binding; Raclopride - pharmacology; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2 - agonists; Receptors, Dopamine D2 - genetics; Receptors, Dopamine D2 - metabolism; Receptors, Metabotropic Glutamate - agonists; Transfection; LY379268; LY354740; AMP; D2S; LC/MS/MS; NMDG; LY2140023; mGlu; MK-801; 3-PPP; LY341495; LY404039; PCP; DA; HPLC; D2L; NSD1015

Some recently published in vitro studies with two metabotropic glutamate 2/3 receptor (mGluR2/3) agonists [(−)-2-oxa-4-aminobicyclo[3.1.0] hexane-4,6-dicarboxylic acid (LY379268) and 1S,2S,5R,6S-2-aminobicyclo[3.1.0]hexane-2,6-bicaroxylate monohydrate (LY354740)] suggest that these compounds may als...