In Vitro and in Vivo Evidence for a Lack of Interaction with Dopamine D2 Receptors by the Metabotropic Glutamate 2/3 Receptor Agonists 1S,2S,5R,6S-2-Aminobicyclo[3.1.0]hexane-2,6-bicaroxylate Monohydrate (LY354740) and (−)-2-Oxa-4-aminobicyclo[3.1.0] Hexane-4,6-dicarboxylic Acid (LY379268) - Fell, Matthew J.; Perry, Kenneth W.; Falcone, Julie F.; Johnson, Bryan G.; Barth, Vanessa N.; Rash, Karen S.; Lucaites, Virginia L.; Threlkeld, Penny G.; Monn, James A.; McKinzie, David L.; Marek, Gerard J.; Svensson, Kjell A.; et al. (The Journal of pharmacology and experimental therapeutics, 2009)
Keywords: Amino Acids - pharmacology; Animals; Binding, Competitive; Bridged Bicyclo Compounds - pharmacology; Bridged Bicyclo Compounds, Heterocyclic - pharmacology; Cell Membrane - drug effects; Cell Membrane - metabolism; CHO Cells; Cricetinae; Cricetulus; Domperidone - pharmacology; Dopamine - biosynthesis; Dopamine D2 Receptor Antagonists; Female; Humans; Male; Mice; Mice, Knockout; Motor Activity - drug effects; Protein Binding; Raclopride - pharmacology; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2 - agonists; Receptors, Dopamine D2 - genetics; Receptors, Dopamine D2 - metabolism; Receptors, Metabotropic Glutamate - agonists; Transfection; LY379268; LY354740; AMP; D2S; LC/MS/MS; NMDG; LY2140023; mGlu; MK-801; 3-PPP; LY341495; LY404039; PCP; DA; HPLC; D2L; NSD1015