Rapid Construction of a Benzo-Fused Indoxamycin Core Enabled by Site-Selective C−H Functionalizations

• Published in: Angewandte Chemie Vol. 128; no. 29; pp. 8410 - 8414
• Main Authors: Bedell, T. Aaron, Hone, Graham A. B., Valette, Damien, Yu, Jin-Quan, Davies, Huw M. L., Sorensen, Erik J.
• Format: Journal Article
• Language: English; German
• Published: Weinheim Blackwell Publishing Ltd 11.07.2016; Wiley Subscription Services, Inc
• Subjects: Architecture; C-H-Aktivierung; Carbenes; Carbon; Chemical bonds; Chemical synthesis; Chemistry; Collaboration; Construction; Cooperation; Design; Hydrogen; Hydrogen bonding; Hydrogen bonds; Insertion; Laboratories; Metabolites; Naturstoffe; Palladierungen; Rhodium-Carbene; Secondary metabolites; Synthesemethoden; Synthesis; Synthesis (chemistry)

Methods for functionalizing carbon–hydrogen bonds are featured in a new synthesis of the tricyclic core architecture that characterizes the indoxamycin family of secondary metabolites. A unique collaboration between three laboratories has engendered a design for synthesis featuring two sequential C−...