In–Vivo Antioxidant activity of ethanolic extract of Mentha pulegium leaf against CCl4 induced toxicity in rats
To evaluate the in–vivo antioxidant potential of ethanolic extract of Mentha Pulegium against CCl4 induced toxicity in rats. Animals were treated with plant extract for 7 days and then toxicity was induced with a single CCl4 intraperitoneal injection. Pre–treatment with 600 mg/kg (p.o.) of ethanolic...
Saved in:
| Published in | Asian Pacific journal of tropical biomedicine Vol. 2; no. 2; pp. S737 - S740 |
|---|---|
| Main Authors | , , |
| Format | Journal Article |
| Language | English |
| Published |
Elsevier B.V
01.02.2012
|
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | To evaluate the in–vivo antioxidant potential of ethanolic extract of Mentha Pulegium against CCl4 induced toxicity in rats.
Animals were treated with plant extract for 7 days and then toxicity was induced with a single CCl4 intraperitoneal injection. Pre–treatment with 600 mg/kg (p.o.) of ethanolic extract of Mentha Pulegium improved the glutathione, SOD, catalase, and peroxidase levels significantly as compared to control group.
The present studies revealed that Mentha Pulegium has significant in–vivo antioxidant activity and can be used to protect tissue from oxidative stress. The result showed that the activities of glutathione, SOD, catalase and peroxidase in group treated with CCl4 declined significantly than that of normal group.
Ethanolic extract of Mentha Pulegium in the dose of 600 mg/kg, p.o., has improved the glutathione, SOD, catalase, and peroxidase levels significantly, which were comparable with Liv 52. Based on this study we conclude that Ethanolic extract of Mentha Pulegium possesses in vivo antioxidant activity and can be employed in protecting tissue from oxidative stress. |
|---|---|
| AbstractList | To evaluate the in–vivo antioxidant potential of ethanolic extract of Mentha Pulegium against CCl4 induced toxicity in rats.
Animals were treated with plant extract for 7 days and then toxicity was induced with a single CCl4 intraperitoneal injection. Pre–treatment with 600 mg/kg (p.o.) of ethanolic extract of Mentha Pulegium improved the glutathione, SOD, catalase, and peroxidase levels significantly as compared to control group.
The present studies revealed that Mentha Pulegium has significant in–vivo antioxidant activity and can be used to protect tissue from oxidative stress. The result showed that the activities of glutathione, SOD, catalase and peroxidase in group treated with CCl4 declined significantly than that of normal group.
Ethanolic extract of Mentha Pulegium in the dose of 600 mg/kg, p.o., has improved the glutathione, SOD, catalase, and peroxidase levels significantly, which were comparable with Liv 52. Based on this study we conclude that Ethanolic extract of Mentha Pulegium possesses in vivo antioxidant activity and can be employed in protecting tissue from oxidative stress. |
| Author | Jain, Dinesh Kumar Balekar, Neelam Jain, Sachin |
| Author_xml | – sequence: 1 givenname: Sachin surname: Jain fullname: Jain, Sachin email: sachin9893459698@gmail.com organization: Department of Pharmacognosy, College of Pharmacy, IPS Academy, Indore MP 452012 India – sequence: 2 givenname: Dinesh Kumar surname: Jain fullname: Jain, Dinesh Kumar organization: Department of Pharmacognosy, College of Pharmacy, IPS Academy, Indore MP 452012 India – sequence: 3 givenname: Neelam surname: Balekar fullname: Balekar, Neelam organization: Department of Pharmacognosy, College of Pharmacy, IPS Academy, Indore MP 452012 India |
| BookMark | eNqFUMtOwzAQtFCRKKWfgOQjHALxJnHcE6oiHpWKOFBxtRx7U4xSpyRu1d74B_6QL8GhcGYvu5rZGe3OKRm4xiEh5yy-YjHj188AwCLGJ-yCwSWPk5hHcESGkAkRTQI5CPPfygkZd91bHIrHAFk6JO8z9_Xx-WK3DZ06b5udNcp5qrS3W-v3tKko-lflmtpqijvfBqYHH9EFmK43NS7tZkVrVBVVS2Vd52lR1Cm1zmw0GuqDp-6trKOt8t0ZOa5U3eH4t4_I4u52UTxE86f7WTGdRxo4gwgNlhlXFUKSZ4AsxdQkRpS5FiYWyvBJqVOGSVoKocDkSQAzXgJUqhRVnoxIdrDVbdN1LVZy3dqVaveSxbJPTv4kJ_tYJAP5k5yEoLs56DDctrXYyk5bdOET26L20jT2H4dvbsl58A |
| CitedBy_id | crossref_primary_10_1016_j_jep_2015_03_016 crossref_primary_10_2174_1871530323666230914103731 crossref_primary_10_3390_antiox7120184 crossref_primary_10_1590_0001_3765201720170446 crossref_primary_10_1016_S1875_5364_18_30057_8 crossref_primary_10_3923_rjphyto_2017_142_149 crossref_primary_10_1016_j_indcrop_2014_06_037 crossref_primary_10_3390_molecules27196728 crossref_primary_10_1515_jcim_2016_0064 crossref_primary_10_1007_s42690_019_00064_z crossref_primary_10_2174_1573401318666220620145213 crossref_primary_10_1016_j_apjtm_2017_03_005 |
| Cites_doi | 10.1080/13880200701741088 10.1111/j.1750-3841.2011.02243.x 10.1016/S1995-7645(11)60193-4 10.33549/physiolres.931088 10.1016/S2222-1808(11)60002-9 10.2174/1381612043384655 10.1016/j.foodchem.2007.10.033 10.1016/j.jep.2007.06.006 10.1016/S1995-7645(11)60214-9 |
| ContentType | Journal Article |
| Copyright | 2012 Asian Pacific Tropical Biomedical Magazine |
| Copyright_xml | – notice: 2012 Asian Pacific Tropical Biomedical Magazine |
| DBID | AAYXX CITATION |
| DOI | 10.1016/S2221-1691(12)60306-2 |
| DatabaseName | CrossRef |
| DatabaseTitle | CrossRef |
| DatabaseTitleList | |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine |
| EISSN | 2588-9222 |
| EndPage | S740 |
| ExternalDocumentID | 10_1016_S2221_1691_12_60306_2 S2221169112603062 |
| GroupedDBID | --- --K -05 -0E -SE -S~ .~1 0R~ 0SF 1~. 1~5 2B. 2C~ 4.4 457 4G. 53G 5VR 5VS 6I. 7-5 92F 92I 92M 93N 93R 9D9 9DE AACTN AAEDT AAEDW AAFTH AALRI AAXUO ABGSF ABJNI ABKZE ABMAC ACGFS ADBBV ADEZE ADMUD ADUVX AEKER AEXQZ AFUIB AGHFR AGYEJ AITUG ALMA_UNASSIGNED_HOLDINGS AMRAJ BAWUL BCNDV CAJEE CAJUS CCEZO CHBEP CIEJG DIK EBS ECGQY EJD FA0 FDB FNPLU GBLVA GROUPED_DOAJ GX1 HYE HZ~ IAO IHR IPNFZ ITC JUIAU KQ8 M41 MO0 NCXOZ O-L O9- OK1 OVD P-8 P-9 PC. Q-- Q-4 Q38 R-E RIG RMW ROL RPM RT5 S.. SDF SES SSZ T8U TCJ TEORI TGQ U1F U1G U5E U5O W3E WFFXF AAYXX ADVLN AKRWK CITATION H13 |
| ID | FETCH-LOGICAL-c2612-edeb56afe23752e14e4d3d8b7c8d08ad69bc41e34b88a2d7308a56b22fab8f73 |
| IEDL.DBID | .~1 |
| ISSN | 2221-1691 |
| IngestDate | Fri Aug 23 00:55:07 EDT 2024 Fri Feb 23 02:24:01 EST 2024 |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 2 |
| Keywords | Superoxide dismutase Liv 52 Mentha Pulegium Antioxidant activity CCl4 |
| Language | English |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c2612-edeb56afe23752e14e4d3d8b7c8d08ad69bc41e34b88a2d7308a56b22fab8f73 |
| ParticipantIDs | crossref_primary_10_1016_S2221_1691_12_60306_2 elsevier_sciencedirect_doi_10_1016_S2221_1691_12_60306_2 |
| PublicationCentury | 2000 |
| PublicationDate | 2012-02-00 |
| PublicationDateYYYYMMDD | 2012-02-01 |
| PublicationDate_xml | – month: 02 year: 2012 text: 2012-02-00 |
| PublicationDecade | 2010 |
| PublicationTitle | Asian Pacific journal of tropical biomedicine |
| PublicationYear | 2012 |
| Publisher | Elsevier B.V |
| Publisher_xml | – name: Elsevier B.V |
| References | Kavitha, Rajamani, Vadivel (bib1) 2010; 4 Kokate (bib7) 1999 Srinivasan, Chandrasekar, Nanjan, Suresh (bib9) 2007; 113 Gordon (bib12) 1990 Erukainure, Ajiboye, Adejobi, Okafor, Sunday (bib3) 2011; 1 Sajeesh, Arunachalam, Parimelazhagan (bib15) 2011; 4 Dhalwal, Shinde, Namdeo, Mahadik (bib13) 2008; 46 Chhajed, Khedekar, Mundhey (bib5) 2007; 16 Biglari, Alkarkhi, Easa (bib8) 2008; 107 Ayoola, Ipav, Sofidiya, Bello, Coker, Odugbemi (bib14) 2008; 1 Ciz, Pavelkova, Gallova, Kralova, Kubala, Lojek (bib11) 2008; 57 Vertuani, Angusti, Manfredini (bib2) 2004; 10 Poongothai, Ponmurugan, Ahmed, Kumar, Sheriff (bib4) 2011; 4 Kalaivani, Rajasekaran, Mathew (bib10) 2011; 76 Khandelwal (bib6) 2000 Kokate (10.1016/S2221-1691(12)60306-2_bib7) 1999 Ciz (10.1016/S2221-1691(12)60306-2_bib11) 2008; 57 Erukainure (10.1016/S2221-1691(12)60306-2_bib3) 2011; 1 Sajeesh (10.1016/S2221-1691(12)60306-2_bib15) 2011; 4 Khandelwal (10.1016/S2221-1691(12)60306-2_bib6) 2000 Dhalwal (10.1016/S2221-1691(12)60306-2_bib13) 2008; 46 Srinivasan (10.1016/S2221-1691(12)60306-2_bib9) 2007; 113 Gordon (10.1016/S2221-1691(12)60306-2_bib12) 1990 Kalaivani (10.1016/S2221-1691(12)60306-2_bib10) 2011; 76 Ayoola (10.1016/S2221-1691(12)60306-2_bib14) 2008; 1 Vertuani (10.1016/S2221-1691(12)60306-2_bib2) 2004; 10 Kavitha (10.1016/S2221-1691(12)60306-2_bib1) 2010; 4 Biglari (10.1016/S2221-1691(12)60306-2_bib8) 2008; 107 Poongothai (10.1016/S2221-1691(12)60306-2_bib4) 2011; 4 Chhajed (10.1016/S2221-1691(12)60306-2_bib5) 2007; 16 |
| References_xml | – volume: 4 start-page: 889 year: 2011 end-page: 899 ident: bib15 article-title: Antioxidant and antipyretic studies on Pothos scandens L publication-title: Asian Pac J Trop Med contributor: fullname: Parimelazhagan – volume: 1 start-page: 5 year: 2011 end-page: 9 ident: bib3 article-title: Protective effect of pineapple (Ananas cosmosus) peel extract of alcohol-induced oxidative stress in brain tissue of male albino rates publication-title: Asian Pac J Trop Dis contributor: fullname: Sunday – volume: 4 start-page: 278 year: 2010 end-page: 285 ident: bib1 article-title: Coleus forskohlii: A comprehensive review on morphology, phytochemistry and pharmacological aspects publication-title: J Med Plant Res contributor: fullname: Vadivel – volume: 1 start-page: 87 year: 2008 end-page: 93 ident: bib14 article-title: Phytochemical screening and free radical scavenging activities of the fruits and leaves of Allanblackia floribunda Oliv. (Guttiferae) publication-title: Int. J. Health Res contributor: fullname: Odugbemi – start-page: 1 year: 1990 end-page: 18 ident: bib12 article-title: The mechanisms of antioxidant action in vitro publication-title: Food antioxidants contributor: fullname: Gordon – volume: 46 start-page: 266 year: 2008 end-page: 272 ident: bib13 article-title: Antioxidant profile and HPTLC densitometric analysis of umbelliferone and psoralen in Aegle marmelos publication-title: Pharm Biol contributor: fullname: Mahadik – volume: 113 start-page: 284 year: 2007 end-page: 291 ident: bib9 article-title: Antioxidant activity of Caesalpinia digyna root publication-title: J Ethonopharmacol contributor: fullname: Suresh – start-page: 149 year: 2000 end-page: 156 ident: bib6 publication-title: Practical Pharmacognosy techniques and experiments contributor: fullname: Khandelwal – volume: 76 start-page: 144 year: 2011 end-page: 149 ident: bib10 article-title: Free radical scavenging, cytotoxic, and hemolytic activities of an active antioxidant compound ethyl gallate from leaves of Acacia nilotica (L.) wild. Ex. Delile subsp. Indica (Benth.) Brenan publication-title: J Food Sci contributor: fullname: Mathew – volume: 107 start-page: 1636 year: 2008 end-page: 1641 ident: bib8 article-title: Antioxidant activity and phenolic content of various date palm (Phoenix dactylifera) fruits publication-title: Iran Food Chem contributor: fullname: Easa – volume: 4 year: 2011 ident: bib4 article-title: Antihyperglycemic and antioxidant effects of Solanum xanthocarpum leaves (field grown & in vitro raised) extract on alloxan induced diabetic rats publication-title: Asian Pac J Trop Med contributor: fullname: Sheriff – volume: 57 start-page: 393 year: 2008 end-page: 402 ident: bib11 article-title: The influence of wine polyphenols on reactive oxygen and nitrogen species production by murine macrophages RAW 264.7 publication-title: Physiol Res contributor: fullname: Lojek – start-page: 149 year: 1999 end-page: 156 ident: bib7 publication-title: Practical Pharmacognosy contributor: fullname: Kokate – volume: 10 start-page: 1677 year: 2004 end-page: 1694 ident: bib2 article-title: The antioxidant and Proantioxidants network: An overview publication-title: Curr Pharm Des contributor: fullname: Manfredini – volume: 16 start-page: 259 year: 2007 end-page: 262 ident: bib5 article-title: Synthesis and free radical scavenging activity of some 1, 3,4-thiazole derivative publication-title: Indian journal of heterocyclic chemistry contributor: fullname: Mundhey – volume: 46 start-page: 266 year: 2008 ident: 10.1016/S2221-1691(12)60306-2_bib13 article-title: Antioxidant profile and HPTLC densitometric analysis of umbelliferone and psoralen in Aegle marmelos publication-title: Pharm Biol doi: 10.1080/13880200701741088 contributor: fullname: Dhalwal – start-page: 149 year: 2000 ident: 10.1016/S2221-1691(12)60306-2_bib6 contributor: fullname: Khandelwal – volume: 76 start-page: 144 year: 2011 ident: 10.1016/S2221-1691(12)60306-2_bib10 article-title: Free radical scavenging, cytotoxic, and hemolytic activities of an active antioxidant compound ethyl gallate from leaves of Acacia nilotica (L.) wild. Ex. Delile subsp. Indica (Benth.) Brenan publication-title: J Food Sci doi: 10.1111/j.1750-3841.2011.02243.x contributor: fullname: Kalaivani – volume: 4 issue: 10 year: 2011 ident: 10.1016/S2221-1691(12)60306-2_bib4 article-title: Antihyperglycemic and antioxidant effects of Solanum xanthocarpum leaves (field grown & in vitro raised) extract on alloxan induced diabetic rats publication-title: Asian Pac J Trop Med doi: 10.1016/S1995-7645(11)60193-4 contributor: fullname: Poongothai – volume: 57 start-page: 393 year: 2008 ident: 10.1016/S2221-1691(12)60306-2_bib11 article-title: The influence of wine polyphenols on reactive oxygen and nitrogen species production by murine macrophages RAW 264.7 publication-title: Physiol Res doi: 10.33549/physiolres.931088 contributor: fullname: Ciz – volume: 1 start-page: 5 issue: 1 year: 2011 ident: 10.1016/S2221-1691(12)60306-2_bib3 article-title: Protective effect of pineapple (Ananas cosmosus) peel extract of alcohol-induced oxidative stress in brain tissue of male albino rates publication-title: Asian Pac J Trop Dis doi: 10.1016/S2222-1808(11)60002-9 contributor: fullname: Erukainure – volume: 10 start-page: 1677 year: 2004 ident: 10.1016/S2221-1691(12)60306-2_bib2 article-title: The antioxidant and Proantioxidants network: An overview publication-title: Curr Pharm Des doi: 10.2174/1381612043384655 contributor: fullname: Vertuani – volume: 1 start-page: 87 year: 2008 ident: 10.1016/S2221-1691(12)60306-2_bib14 article-title: Phytochemical screening and free radical scavenging activities of the fruits and leaves of Allanblackia floribunda Oliv. (Guttiferae) publication-title: Int. J. Health Res contributor: fullname: Ayoola – start-page: 149 year: 1999 ident: 10.1016/S2221-1691(12)60306-2_bib7 contributor: fullname: Kokate – volume: 4 start-page: 278 year: 2010 ident: 10.1016/S2221-1691(12)60306-2_bib1 article-title: Coleus forskohlii: A comprehensive review on morphology, phytochemistry and pharmacological aspects publication-title: J Med Plant Res contributor: fullname: Kavitha – volume: 107 start-page: 1636 year: 2008 ident: 10.1016/S2221-1691(12)60306-2_bib8 article-title: Antioxidant activity and phenolic content of various date palm (Phoenix dactylifera) fruits publication-title: Iran Food Chem doi: 10.1016/j.foodchem.2007.10.033 contributor: fullname: Biglari – volume: 113 start-page: 284 year: 2007 ident: 10.1016/S2221-1691(12)60306-2_bib9 article-title: Antioxidant activity of Caesalpinia digyna root publication-title: J Ethonopharmacol doi: 10.1016/j.jep.2007.06.006 contributor: fullname: Srinivasan – start-page: 1 year: 1990 ident: 10.1016/S2221-1691(12)60306-2_bib12 article-title: The mechanisms of antioxidant action in vitro contributor: fullname: Gordon – volume: 16 start-page: 259 year: 2007 ident: 10.1016/S2221-1691(12)60306-2_bib5 article-title: Synthesis and free radical scavenging activity of some 1, 3,4-thiazole derivative publication-title: Indian journal of heterocyclic chemistry contributor: fullname: Chhajed – volume: 4 start-page: 889 issue: 11 year: 2011 ident: 10.1016/S2221-1691(12)60306-2_bib15 article-title: Antioxidant and antipyretic studies on Pothos scandens L publication-title: Asian Pac J Trop Med doi: 10.1016/S1995-7645(11)60214-9 contributor: fullname: Sajeesh |
| SSID | ssj0000602254 |
| Score | 2.0454946 |
| Snippet | To evaluate the in–vivo antioxidant potential of ethanolic extract of Mentha Pulegium against CCl4 induced toxicity in rats.
Animals were treated with plant... |
| SourceID | crossref elsevier |
| SourceType | Aggregation Database Publisher |
| StartPage | S737 |
| SubjectTerms | Antioxidant activity CCl4 Liv 52 Mentha Pulegium Superoxide dismutase |
| Title | In–Vivo Antioxidant activity of ethanolic extract of Mentha pulegium leaf against CCl4 induced toxicity in rats |
| URI | https://dx.doi.org/10.1016/S2221-1691(12)60306-2 |
| Volume | 2 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV07T8MwELYqBsSCeIpn5YEBhtDacRxnrCqqggQLBXWL7NiGSCUt0CImxH_gH_JLuEtSHhJiYLXiU_T58t35cg9CDqTUyiUx3E24iAOhQxFoLpPAgQIYo7UVEouTzy9k_0qcDaNhg3TntTCYVllzf8XpJVvXK60azdYkz1uXYNkYtnph4JKD44s8LMAYgU4fv7DPOEtbgpUqh6Hh8wFu-CrkqYSUi4eMH5VyAv67ifpmdnorZLn2F2mneqVV0nDFGlk8r_-Ir5P70-L99e06fxrTDiYuPucWsKJYroBTIejYU4fRcWz_S4GIsSgKF7F3z62mk9nI3eSzOzpy2lN9o3NwF2m3OxIULutw7JZOQWaGovKCgro8bpBB72TQ7Qf1GIUgw_5ggbPORFJ7x8M44o4JJ2xolYkzZdtKW5mYTDAXCqOU5hY-eaUjaTj32igfh5tkoRgXbotQZtuGZVrEziei7XiiuWdZhhxhfRb5bXI8By6dVM0y0s8sMkQ6RaRTxtMS6ZRvEzWHN_1x6ikQ-t9bd_6_dZcsgdvDq9zrPbIwfZi5fXAtpqZZ6k6zjPl8ANmEyeU |
| link.rule.ids | 315,786,790,4521,27957,27958,45620 |
| linkProvider | Elsevier |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3LTtwwFLUQSKUbBKWoPApedFEWYcaO4zjL0YjRQBk2HRA7y45tiDRkBphBrBD_wB_yJb03yfCQqi66tXSvohPn3GPnPgj5IaVRPkvhbMJFGgkTi8hwmUUeNoC1xjghsTh5cCr7Z-L4IrlYIN15LQymVTbcX3N6xdbNSqtBszUpitZviGwMW70wkOQgfIGHl1DO4_yGg0f2etHSlhCmqmloaBChxVslT-2lWvzJ-H7lKOJ_j1Hv4k5vlaw0gpF26mdaIwu-_EI-DZpf4uvk5qh8eXo-L-7HtIOZiw-FA7Ao1ivgWAg6DtTj9Tj2_6XAxFgVhYvYvOfK0Mls5C-L2TUdeROouTQF6EXa7Y4EhdM6vHdHp-AzR1dFSWG_3H0lw97hsNuPmjkKUY4NwiLvvE2kCZ7HacI9E1642Cmb5sq1lXEys7lgPhZWKcMdfPPKJNJyHoxVIY03yGI5Lv03QplrW5YbkfqQibbnmeGB5TmShAt5EjbJwRw4Pam7ZejXNDJEWiPSmnFdIa35JlFzePWH166B0f9tuvX_pntkuT8cnOiTo9Nf2-QzaCBeJ2LvkMXp7cx_B50xtbvVPvoDTcvL9Q |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=In%E2%80%93Vivo+Antioxidant+activity+of+ethanolic+extract+of+Mentha+pulegium+leaf+against+CCl4+induced+toxicity+in+rats&rft.jtitle=Asian+Pacific+journal+of+tropical+biomedicine&rft.au=Jain%2C+Sachin&rft.au=Jain%2C+Dinesh+Kumar&rft.au=Balekar%2C+Neelam&rft.date=2012-02-01&rft.issn=2221-1691&rft.volume=2&rft.issue=2&rft.spage=S737&rft.epage=S740&rft_id=info:doi/10.1016%2FS2221-1691%2812%2960306-2&rft.externalDBID=n%2Fa&rft.externalDocID=10_1016_S2221_1691_12_60306_2 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2221-1691&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2221-1691&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2221-1691&client=summon |