Genetically engineered human induced pluripotent stem cells for the production of brain-targeting extracellular vesicles

• Published in: Stem cell research & therapy Vol. 15; no. 1; p. 345
• Main Authors: Tang, Fan, Dong, Tao, Zhou, Chengqian, Deng, Leon, Liu, Hans B, Wang, Wenshen, Liu, Guanshu, Ying, Mingyao, Li, Pan P
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 08.10.2024; BioMed Central
• Subjects: Animals; Brain - metabolism; Chromosomes; CRISPR-Cas Systems; Drug delivery systems; Drugs; Ethylenediaminetetraacetic acid; Extracellular Vesicles - metabolism; Genetic Engineering; Genetically modified organisms; Glycoproteins - genetics; Glycoproteins - metabolism; Health aspects; Humans; Induced Pluripotent Stem Cells - cytology; Induced Pluripotent Stem Cells - metabolism; Mice; Neurons; Peptide Fragments; Peptides; Scientific equipment and supplies industry; Stem cells; Vehicles; Viral Proteins; United States

Extracellular vesicles (EVs) are cell-secreted membrane vesicles that have become a promising, natural nanoparticle system for delivering either naturally carried or exogenously loaded therapeutic molecules. Among reported cell sources for EV manufacture, human induced pluripotent stem cells (hiPSCs...