Clear Cell Adenocarcinoma of the Ureter Similar to Clear Cell Renal Cell Carcinoma Histology

A 70-year-old woman was referred to our hospital with gross hematuria and diagnosed with right invasive ureteral cancer and bladder urothelial carcinoma in situ. Intravesical BCG therapy and neoadjuvant chemotherapy with carboplatin and gemcitabine were performed at the same time. Subsequently, lapa...

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Published inCase reports in urology Vol. 2021; pp. 1 - 4
Main Authors Watanabe, Kazuhiro, Hasegawa, Go, Ikeda, Yohei, Hara, Noboru, Nishiyama, Tsutomu
Format Journal Article
LanguageEnglish
Published New York Hindawi 28.05.2021
Hindawi Limited
Wiley
Subjects
Bladder
Bladder cancer
Cancer therapies
Case Report
Case reports
Chemotherapy
Creatinine
Cytoplasm
Histology
Kidney cancer
Laparoscopy
Pathology
Prostate
Tumors
Urogenital system
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Summary:A 70-year-old woman was referred to our hospital with gross hematuria and diagnosed with right invasive ureteral cancer and bladder urothelial carcinoma in situ. Intravesical BCG therapy and neoadjuvant chemotherapy with carboplatin and gemcitabine were performed at the same time. Subsequently, laparoscopic right nephroureterectomy was performed. Urothelial carcinoma in situ persisted; however, most of the tumor was clear cell carcinoma. The clear cell carcinoma lesion had clear cytoplasm with round nuclei and visible nucleoli in an insular arrangement as is the case with clear cell renal cell carcinoma. No transitional lesion between clear cell adenocarcinoma and urothelial carcinoma was presented. The clear cell carcinoma lesion was GATA3 negative and HNF4α positive; however, the urothelial cancer lesion was GATA3 positive and HNF4α negative. Clear cell carcinoma was diagnosed as clear cell adenocarcinoma similar to clear cell renal cell carcinoma histology.
Bibliography:Academic Editor: Fumitaka Koga
ISSN:2090-696X
2090-6978
DOI:10.1155/2021/5599014