Ontogeny of the Glucagon-Like Peptide-2 Receptor Axis in the Developing Rat IntestineThis work was supported in part by operating grants from the Medical Research Council (to D.J.D. and P.L.B.), the Crohn’s and Colitis Foundation of Canada (to P.L.B.), and the Ontario Research and Development Challenge Fund (to D.J.D.). GLP-2 is the subject of a licensing agreement between Toronto General Hospital, the University of Toronto, D.J.D., and NPS Allelix Corp

• Published in: Endocrinology (Philadelphia) Vol. 141; no. 11; pp. 4194 - 4201
• Main Authors: Lovshin, Julie, Yusta, Bernardo, Iliopoulos, Ilias, Migirdicyan, Anoush, Dableh, Liliane, Brubaker, Patricia L., Drucker, Daniel J.
• Format: Journal Article
• Language: English
• Published: Washington Oxford University Press 01.11.2000
• Subjects: Body mass; Colitis; Epithelium; Fetuses; Gene expression; Glucagon; Glucagon-like peptide 2; Ileum; Immunoreactivity; Intestine; Jejunum; Medical research; Neonates; Ontogeny; Peptides; R&D; Receptors; Research & development; Small intestine; Stomach

Glucagon-like peptide-2 (GLP-2) is secreted by enteroendocrine cells in the small and large intestines and exerts intestinotropic effects in the gastrointestinal mucosal epithelium of the adult rodent. The actions of GLP-2 are mediated by the GLP-2 receptor, a new member of the G protein-coupled rec...