Clinical significance of elevation of serum CA125 level in patients with metastatic bladder carcinoma
Objective: To explore the clinical significance of the examination of serum CA125 level of patients with metastatic bladder carcinoma. Methods: Electrochemiluminescence technique was used to examine the serum CA125 concentration of 58 cases with metastatic bladder cancer. 30 cases of superficial bla...
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Published in | The Chinese-German journal of clinical oncology Vol. 7; no. 8; pp. 477 - 479 |
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Main Authors | , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Berlin/Heidelberg
Springer-Verlag
2008
Department of Urology, Dalian Friendship Hospital, Dalian 116001, China%Central Laboratory, Dalian Friendship Hospital, Dalian 116001, China |
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Abstract | Objective: To explore the clinical significance of the examination of serum CA125 level of patients with metastatic bladder carcinoma. Methods: Electrochemiluminescence technique was used to examine the serum CA125 concentration of 58 cases with metastatic bladder cancer. 30 cases of superficial bladder cancer and 8 cases of other urological diseases were collected as the control group. Results: Serum CA125 level in 39 (67.2%) out of 58 cases ranged from 36.7 U/mL to 1485.6 U/mL (mean 496.3 U/mL), being higher than normal (〈 35 U/mL). Serum CA125 level of metastatic bladder cancer patients was 324.5 U/mL, significantly higher than that in control group (P 〈 0.001). Serum CA125 level of 10 patients after transurethral resection operation was significantly lower than that before operation (P 〈 0.05). Serum CA125 level of 16 patients who refused further treatment significantly increased from 450.4 U/mL, to 505.8 U/mL (P = 0.041) 3 months after discharge from the hospital. Serum CA125 level of 17 patients significantly decreased from 475.8 U/L to 237.9 U/mL (P 〈 0.001 ) after bilateral iliac-artedal embolism treatment. Conclusion: CA125 may be a valuable marker for the judgment of advanced metastatic bladder cancer. |
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AbstractList | R73; Objective: To explore the clinical significance of the examination of serum CA125 level of patients with metastatic bladder carcinoma.Methods: Electrochemiluminescance technique was used to examine the serum CA125 concentration of 58 cases with metastatic bladder cancer.30 cases of superficial bladder cancer and 8 cases of other urological diseases were collected as the control group.Results: Serum CA125 level in 39 (67.2%) out of 58 cases ranged from 36.7 U/mL to 1485.6 U/mL (mean 498.3 U/mL), being higher than normal (<35 U/mL).Serum CA125 level of metastatic bladder cancer patientswas 324.5 U/mL, significantly higher than that in control group (P<0.001).Serum CA125 level of 10 patients after transurethral resection operation was significantly lower than that before operation (P<0.05).Serum CA125 level of 16 patients whorefused further treatment significantly increased from 450.4 U/mL, to 505.8 U/mL (P = 0.041) 3 months after discharge from the hospital.Serum CA125 level of 17 patients significantly decreased from 475.8 U/L to 237.9 U/mL (P<0.001 ) after bilaterallilac-arterial embolism treatment.Conclusion: CA125 may be a valuable marker for the judgment of advanced metastatic bladder cancer. Objective To explore the clinical significance of the examination of serum CA125 level of patients with metastatic bladder carcinoma. Methods Electrochemiluminescence technique was used to examine the serum CA125 concentration of 58 cases with metastatic bladder cancer. 30 cases of superficial bladder cancer and 8 cases of other urological diseases were collected as the control group. Results Serum CA125 level in 39 (67.2%) out of 58 cases ranged from 36.7 U/mL to 1485.6 U/mL (mean 498.3 U/mL), being higher than normal (< 35 U/mL). Serum CA125 level of metastatic bladder cancer patients was 324.5 U/mL, significantly higher than that in control group ( P < 0.001). Serum CA125 level of 10 patients after transurethral resection operation was significantly lower than that before operation ( P < 0.05). Serum CA125 level of 16 patients who refused further treatment significantly increased from 450.4 U/mL, to 505.8 U/mL ( P = 0.041) 3 months after discharge from the hospital. Serum CA125 level of 17 patients significantly decreased from 475.8 U/L to 237.9 U/mL ( P < 0.001) after bilateral iliac-arterial embolism treatment. Conclusion CA125 may be a valuable marker for the judgment of advanced metastatic bladder cancer. Objective: To explore the clinical significance of the examination of serum CA125 level of patients with metastatic bladder carcinoma. Methods: Electrochemiluminescence technique was used to examine the serum CA125 concentration of 58 cases with metastatic bladder cancer. 30 cases of superficial bladder cancer and 8 cases of other urological diseases were collected as the control group. Results: Serum CA125 level in 39 (67.2%) out of 58 cases ranged from 36.7 U/mL to 1485.6 U/mL (mean 496.3 U/mL), being higher than normal (〈 35 U/mL). Serum CA125 level of metastatic bladder cancer patients was 324.5 U/mL, significantly higher than that in control group (P 〈 0.001). Serum CA125 level of 10 patients after transurethral resection operation was significantly lower than that before operation (P 〈 0.05). Serum CA125 level of 16 patients who refused further treatment significantly increased from 450.4 U/mL, to 505.8 U/mL (P = 0.041) 3 months after discharge from the hospital. Serum CA125 level of 17 patients significantly decreased from 475.8 U/L to 237.9 U/mL (P 〈 0.001 ) after bilateral iliac-artedal embolism treatment. Conclusion: CA125 may be a valuable marker for the judgment of advanced metastatic bladder cancer. |
Author | Jinyi Yang Wei Wei Jianguang Liu Xiaoqi Hu Lin Ye Jie Zhou Hongbo Jiang Xingjin Jiang |
AuthorAffiliation | Department of Urology, Dalian Friendship Hospital, Dalian 116001, China Central Laboratory, Dalian Friendship Hospital, Dalian 116001, China |
AuthorAffiliation_xml | – name: Department of Urology, Dalian Friendship Hospital, Dalian 116001, China%Central Laboratory, Dalian Friendship Hospital, Dalian 116001, China |
Author_xml | – sequence: 1 givenname: Jinyi surname: Yang fullname: Yang, Jinyi email: yangjinyi90@hotmail.com organization: Department of Urology, Dalian Friendship Hospital – sequence: 2 givenname: Wei surname: Wei fullname: Wei, Wei organization: Department of Urology, Dalian Friendship Hospital – sequence: 3 givenname: Jianguang surname: Liu fullname: Liu, Jianguang organization: Department of Urology, Dalian Friendship Hospital – sequence: 4 givenname: Xiaoqi surname: Hu fullname: Hu, Xiaoqi organization: Department of Urology, Dalian Friendship Hospital – sequence: 5 givenname: Lin surname: Ye fullname: Ye, Lin organization: Department of Urology, Dalian Friendship Hospital – sequence: 6 givenname: Jie surname: Zhou fullname: Zhou, Jie organization: Central Laboratory, Dalian Friendship Hospital – sequence: 7 givenname: Hongbo surname: Jiang fullname: Jiang, Hongbo organization: Department of Urology, Dalian Friendship Hospital – sequence: 8 givenname: Xingjin surname: Jiang fullname: Jiang, Xingjin organization: Department of Urology, Dalian Friendship Hospital |
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Cites_doi | 10.1200/JCO.2003.05.101 10.1016/S0022-5347(05)64042-6 10.1016/S0022-5347(05)66240-4 10.1002/1097-0215(20001120)89:6<519::AID-IJC9>3.0.CO;2-# 10.1016/S0022-5347(17)38271-X |
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DocumentTitleAlternate | Clinical significance of elevation of serum CA125 level in patients with metastatic bladder carcinoma |
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Keywords | bladder neoplasms carcinoma CA125 antigen ceroinoma |
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Notes | bladder neoplasms bladder neoplasms; carcinoma; CA125 antigen R737.14 carcinoma CA125 antigen 42-1654/R |
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References | Madersbacher, Hochreiter, Burkhard (CR1) 2003; 21 Izes, Dyer, Callum (CR6) 2001; 165 Retz, Lehmann, Amann (CR3) 2003; 169 Hogdall, Hogdall, Tingulstad (CR4) 2000; 89 Deng, Wu, Jiang (CR2) 2000; 38 Guarnaccia, Pais, Grous (CR5) 1991; 145 S. Madersbacher (51_CR1) 2003; 21 M. Retz (51_CR3) 2003; 169 X. Deng (51_CR2) 2000; 38 E.V. Hogdall (51_CR4) 2000; 89 S. Guarnaccia (51_CR5) 1991; 145 J.K. Izes (51_CR6) 2001; 165 |
References_xml | – volume: 21 start-page: 690 year: 2003 end-page: 696 ident: CR1 article-title: Radical cystectomy for bladder cancer today — a homogeneous series without neoadjuvant therapy publication-title: J Clin Oncol doi: 10.1200/JCO.2003.05.101 contributor: fullname: Burkhard – volume: 145 start-page: 140 year: 1991 end-page: 141 ident: CR5 article-title: Adenocarcinoma of the urachus associated with elevated levels of CA125 publication-title: J Urol contributor: fullname: Grous – volume: 38 start-page: 278 year: 2000 end-page: 279 ident: CR2 article-title: Preoperative superselective intra-internal iliac arterial chemotherapy for invasive bladder cancer and curative analysis publication-title: Chin J Surg (Chinese) contributor: fullname: Jiang – volume: 169 start-page: 86 year: 2003 end-page: 89 ident: CR3 article-title: Mucin 7 and cytokeratin 20 as new diagnostic urinary markers for bladder tumor publication-title: J Urol doi: 10.1016/S0022-5347(05)64042-6 contributor: fullname: Amann – volume: 165 start-page: 1908 year: 2001 end-page: 1913 ident: CR6 article-title: CA125 as a marker of tumor activity in advanced urothelial malignancy publication-title: J Urol doi: 10.1016/S0022-5347(05)66240-4 contributor: fullname: Callum – volume: 89 start-page: 519 year: 2000 end-page: 523 ident: CR4 article-title: Predictive values of serum tumor markers tetranectin, OVX1, CASA and CA125 in patients with a pelvic mass publication-title: Int J Cancer doi: 10.1002/1097-0215(20001120)89:6<519::AID-IJC9>3.0.CO;2-# contributor: fullname: Tingulstad – volume: 38 start-page: 278 year: 2000 ident: 51_CR2 publication-title: Chin J Surg (Chinese) contributor: fullname: X. Deng – volume: 21 start-page: 690 year: 2003 ident: 51_CR1 publication-title: J Clin Oncol doi: 10.1200/JCO.2003.05.101 contributor: fullname: S. Madersbacher – volume: 145 start-page: 140 year: 1991 ident: 51_CR5 publication-title: J Urol doi: 10.1016/S0022-5347(17)38271-X contributor: fullname: S. Guarnaccia – volume: 89 start-page: 519 year: 2000 ident: 51_CR4 publication-title: Int J Cancer doi: 10.1002/1097-0215(20001120)89:6<519::AID-IJC9>3.0.CO;2-# contributor: fullname: E.V. Hogdall – volume: 165 start-page: 1908 year: 2001 ident: 51_CR6 publication-title: J Urol doi: 10.1016/S0022-5347(05)66240-4 contributor: fullname: J.K. Izes – volume: 169 start-page: 86 year: 2003 ident: 51_CR3 publication-title: J Urol doi: 10.1016/S0022-5347(05)64042-6 contributor: fullname: M. Retz |
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Title | Clinical significance of elevation of serum CA125 level in patients with metastatic bladder carcinoma |
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