Clinical significance of elevation of serum CA125 level in patients with metastatic bladder carcinoma

• Published in: The Chinese-German journal of clinical oncology Vol. 7; no. 8; pp. 477 - 479
• Main Authors: Yang, Jinyi, Wei, Wei, Liu, Jianguang, Hu, Xiaoqi, Ye, Lin, Zhou, Jie, Jiang, Hongbo, Jiang, Xingjin
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer-Verlag 2008; Department of Urology, Dalian Friendship Hospital, Dalian 116001, China%Central Laboratory, Dalian Friendship Hospital, Dalian 116001, China
• Subjects: CAl25检测; Cancer Research; Medicine; Medicine & Public Health; Oncology; Surgical Oncology; 临床意义; 晚期转移性膀胱癌; bladder neoplasms; carcinoma; CA125 antigen; ceroinoma
• ISSN: 1610-1979; 1613-9089
• DOI: 10.1007/s10330-008-0051-x

Objective： To explore the clinical significance of the examination of serum CA125 level of patients with metastatic bladder carcinoma. Methods： Electrochemiluminescence technique was used to examine the serum CA125 concentration of 58 cases with metastatic bladder cancer. 30 cases of superficial bladder cancer and 8 cases of other urological diseases were collected as the control group. Results： Serum CA125 level in 39 （67.2%） out of 58 cases ranged from 36.7 U/mL to 1485.6 U/mL （mean 496.3 U/mL）, being higher than normal （〈 35 U/mL）. Serum CA125 level of metastatic bladder cancer patients was 324.5 U/mL, significantly higher than that in control group （P 〈 0.001）. Serum CA125 level of 10 patients after transurethral resection operation was significantly lower than that before operation （P 〈 0.05）. Serum CA125 level of 16 patients who refused further treatment significantly increased from 450.4 U/mL, to 505.8 U/mL （P = 0.041） 3 months after discharge from the hospital. Serum CA125 level of 17 patients significantly decreased from 475.8 U/L to 237.9 U/mL （P 〈 0.001 ） after bilateral iliac-artedal embolism treatment. Conclusion： CA125 may be a valuable marker for the judgment of advanced metastatic bladder cancer.