Visible-light-mediated de-aminative alkylation of N-arylamines with alkyl Katritzky salts

• Published in: ORGANIC CHEMISTRY FRONTIERS Vol. 6; no. 23; pp. 3902 - 3905
• Main Authors: Xu, Yuliang, Xu, Ze-Jun, Liu, Zhao-Peng, Lou, Hongxiang
• Format: Journal Article
• Language: English
• Published: CAMBRIDGE Royal Soc Chemistry 07.12.2019; Royal Society of Chemistry
• Subjects: Alkylation; Amines; Chemistry; Chemistry, Organic; Functional groups; Natural products; NMR; Nuclear magnetic resonance; Organic chemistry; Organic compounds; Peptides; Physical Sciences; Salts; Science & Technology; Substrates; SP C-H; ACTIVATION; CROSS-COUPLINGS; TETRAHYDROISOQUINOLINES; DEHYDROGENATIVE-COUPLING REACTION; PHOTOCATALYSIS; BOND FUNCTIONALIZATION; INDOLATION; EFFICIENT; BENZYLIC AMINES

A visible-light-mediated de-aminative alkylation of N-arylamines has been developed, providing direct access to alpha-amino C-H functionalization from readily available Katritzky salts under mild conditions. In some cases, this operationally simple protocol can be performed in the absence of a photo...