Visible-light-mediated de-aminative alkylation of N-arylamines with alkyl Katritzky salts
A visible-light-mediated de-aminative alkylation of N-arylamines has been developed, providing direct access to alpha-amino C-H functionalization from readily available Katritzky salts under mild conditions. In some cases, this operationally simple protocol can be performed in the absence of a photo...
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| Published in | ORGANIC CHEMISTRY FRONTIERS Vol. 6; no. 23; pp. 3902 - 3905 |
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| Main Authors | , , , |
| Format | Journal Article |
| Language | English |
| Published |
CAMBRIDGE
Royal Soc Chemistry
07.12.2019
Royal Society of Chemistry |
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| Online Access | Get full text |
| ISSN | 2052-4129 2052-4110 2052-4110 |
| DOI | 10.1039/c9qo01175g |
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| Abstract | A visible-light-mediated de-aminative alkylation of N-arylamines has been developed, providing direct access to alpha-amino C-H functionalization from readily available Katritzky salts under mild conditions. In some cases, this operationally simple protocol can be performed in the absence of a photocatalyst. A wide range of substrates and functional groups are tolerated. The utility of this approach is highlighted by its application to the late-state modification of drug molecules, natural products and peptides. |
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| AbstractList | A visible-light-mediated de-aminative alkylation of N-arylamines has been developed, providing direct access to α-amino C–H functionalization from readily available Katritzky salts under mild conditions. In some cases, this operationally simple protocol can be performed in the absence of a photocatalyst. A wide range of substrates and functional groups are tolerated. The utility of this approach is highlighted by its application to the late-state modification of drug molecules, natural products and peptides. A visible-light-mediated de-aminative alkylation of N-arylamines has been developed, providing direct access to alpha-amino C-H functionalization from readily available Katritzky salts under mild conditions. In some cases, this operationally simple protocol can be performed in the absence of a photocatalyst. A wide range of substrates and functional groups are tolerated. The utility of this approach is highlighted by its application to the late-state modification of drug molecules, natural products and peptides. |
| Author | Lou, Hongxiang Liu, Zhao-Peng Xu, Yuliang Xu, Ze-Jun |
| Author_xml | – sequence: 1 givenname: Yuliang surname: Xu fullname: Xu, Yuliang organization: Shandong Univ, Sch Pharm, Key Lab Chem Biol, Minist Educ, 44 West Wenhua Rd, Jinan 250012, Shandong, Peoples R China – sequence: 2 givenname: Ze-Jun surname: Xu fullname: Xu, Ze-Jun organization: Shandong Univ, Sch Pharm, Key Lab Chem Biol, Minist Educ, 44 West Wenhua Rd, Jinan 250012, Shandong, Peoples R China – sequence: 3 givenname: Zhao-Peng surname: Liu fullname: Liu, Zhao-Peng email: liuzhaop@sdu.edu.cn organization: Shandong Univ, Sch Pharm, Key Lab Chem Biol, Minist Educ, 44 West Wenhua Rd, Jinan 250012, Shandong, Peoples R China – sequence: 4 givenname: Hongxiang surname: Lou fullname: Lou, Hongxiang email: louhongxiang@sdu.edu.cn organization: Shandong Univ, Sch Pharm, Key Lab Chem Biol, Minist Educ, 44 West Wenhua Rd, Jinan 250012, Shandong, Peoples R China |
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| Keywords | SP C-H ACTIVATION CROSS-COUPLINGS TETRAHYDROISOQUINOLINES DEHYDROGENATIVE-COUPLING REACTION PHOTOCATALYSIS BOND FUNCTIONALIZATION INDOLATION EFFICIENT BENZYLIC AMINES |
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| Snippet | A visible-light-mediated de-aminative alkylation of N-arylamines has been developed, providing direct access to alpha-amino C-H functionalization from readily... A visible-light-mediated de-aminative alkylation of N-arylamines has been developed, providing direct access to α-amino C–H functionalization from readily... |
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| SubjectTerms | Alkylation Amines Chemistry Chemistry, Organic Functional groups Natural products NMR Nuclear magnetic resonance Organic chemistry Organic compounds Peptides Physical Sciences Salts Science & Technology Substrates |
| Title | Visible-light-mediated de-aminative alkylation of N-arylamines with alkyl Katritzky salts |
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