Copper-catalyzed formal [4+1] annulation of N-propargyl ynamides with diketones

• Published in: ORGANIC CHEMISTRY FRONTIERS Vol. 10; no. 1; pp. 203 - 208
• Main Authors: Xu, Hao-Jin, Li, Cui-Ting, Chen, Can-Ming, Chen, Jie, Zhu, Xin-Qi, Zhou, Bo, Ye, Long-Wu
• Format: Journal Article
• Language: English
• Published: CAMBRIDGE Royal Soc Chemistry 20.12.2022; Royal Society of Chemistry
• Subjects: Atom economy; Chemical reactions; Chemistry; Chemistry, Organic; Copper; Diketones; Organic chemistry; Physical Sciences; Science & Technology; YLIDES; CYCLOADDITION; ACCESS

An efficient copper-catalyzed formal [4 + 1] annulation of N-propargyl ynamides with diketones is described. This protocol enables practical and atom-economic synthesis of valuable pyrrole-substituted dioxoles in generally moderate to excellent yields under mild reaction conditions. Thus, two new fi...