Synthesis of 2-acetylpyridine-N-substituted thiosemicarbazonates of copper(ii) with high antimicrobial activity against methicillin resistant S. aureus, K. pneumoniae 1 and C. albicans

• Published in: New journal of chemistry Vol. 43; no. 29; pp. 11727 - 11742
• Main Authors: Kaushal, Mani, Lobana, Tarlok S., Nim, Lovedeep, Bala, Ritu, Arora, Daljit S., Garcia-Santos, Isabel, Duff, Courtney E., Jasinski, Jerry P.
• Format: Journal Article
• Language: English
• Published: CAMBRIDGE Royal Soc Chemistry 2019; Royal Society of Chemistry
• Subjects: Antiinfectives and antibacterials; Antimicrobial agents; Chemistry; Chemistry, Multidisciplinary; Coordination compounds; Copper; Copper compounds; Crystallography; Electron transfer; Halides; Infrared spectroscopy; Microorganisms; Physical Sciences; Salmonella; Science & Technology; Staphylococcus infections; Substitutes; IN-VITRO; PLATINUM(II) COMPLEXES; C-2 CARBON; CRYSTAL-STRUCTURE; SPECTROSCOPIC PROPERTIES; STRUCTURAL-CHARACTERIZATION; 2-ACETYL PYRIDINE; CYTOTOXIC ACTIVITY; METAL-COMPLEXES; ZINC(II) COMPLEXES

The basic interest in the present study pertains to developing metal based antimicrobial agents, as several microorganisms have built resistance to the conventional drugs. In this respect, reactions of 2-acetylpyridine-N-1-substituted thiosemicarbazones, {(C5H4N4)-(CH3)(CN3)-N-2-N-2(H)-C-1(S)-(NHR)-...