Transition metal-free synthesis of 3-trifluoromethyl chromones via tandem C-H trifluoromethylation and chromone annulation of enaminones
The tandem C-H bond trifluoromethylation and chromone annulation reactions ofo-hydroxyphenyl enaminones have been realized for the practical synthesis of 3-trifluoromethyl chromones. The reactions are performed efficiently with the promotion of K(2)S(2)O(8)without using any transition metal catalyst...
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| Published in | ORGANIC CHEMISTRY FRONTIERS Vol. 7; no. 18; pp. 2770 - 2775 |
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| Main Authors | , , |
| Format | Journal Article |
| Language | English |
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Royal Soc Chemistry
21.09.2020
Royal Society of Chemistry |
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| Abstract | The tandem C-H bond trifluoromethylation and chromone annulation reactions ofo-hydroxyphenyl enaminones have been realized for the practical synthesis of 3-trifluoromethyl chromones. The reactions are performed efficiently with the promotion of K(2)S(2)O(8)without using any transition metal catalyst or additive. In addition, the 3-trifluoromethyl chromone products have been successfully used for the synthesis of 3-trifluoromethyl pyrimidines by reacting with guanidine/amidine substrates. |
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| AbstractList | The tandem C-H bond trifluoromethylation and chromone annulation reactions ofo-hydroxyphenyl enaminones have been realized for the practical synthesis of 3-trifluoromethyl chromones. The reactions are performed efficiently with the promotion of K(2)S(2)O(8)without using any transition metal catalyst or additive. In addition, the 3-trifluoromethyl chromone products have been successfully used for the synthesis of 3-trifluoromethyl pyrimidines by reacting with guanidine/amidine substrates. The tandem C–H bond trifluoromethylation and chromone annulation reactions of o-hydroxyphenyl enaminones have been realized for the practical synthesis of 3-trifluoromethyl chromones. The reactions are performed efficiently with the promotion of K2S2O8 without using any transition metal catalyst or additive. In addition, the 3-trifluoromethyl chromone products have been successfully used for the synthesis of 3-trifluoromethyl pyrimidines by reacting with guanidine/amidine substrates. |
| Author | Yu, Qing Liu, Yunyun Wan, Jie-Ping |
| Author_xml | – sequence: 1 givenname: Qing surname: Yu fullname: Yu, Qing organization: Jiangxi Normal Univ, Coll Chem & Chem Engn, Nanchang 330022, Jiangxi, Peoples R China – sequence: 2 givenname: Yunyun surname: Liu fullname: Liu, Yunyun organization: Jiangxi Normal Univ, Coll Chem & Chem Engn, Nanchang 330022, Jiangxi, Peoples R China – sequence: 3 givenname: Jie-Ping orcidid: 0000-0002-9367-8384 surname: Wan fullname: Wan, Jie-Ping email: wanjieping@jxnu.edu.cn organization: Jiangxi Normal Univ, Coll Chem & Chem Engn, Nanchang 330022, Jiangxi, Peoples R China |
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| Snippet | The tandem C-H bond trifluoromethylation and chromone annulation reactions ofo-hydroxyphenyl enaminones have been realized for the practical synthesis of... The tandem C–H bond trifluoromethylation and chromone annulation reactions of o-hydroxyphenyl enaminones have been realized for the practical synthesis of... |
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| SubjectTerms | Cascade chemical reactions Catalysts Chemical reactions Chemistry Chemistry, Organic Guanidine Hydrogen bonds Organic chemistry Physical Sciences Potassium persulfate Pyrimidines Science & Technology Substrates Transition metals |
| Title | Transition metal-free synthesis of 3-trifluoromethyl chromones via tandem C-H trifluoromethylation and chromone annulation of enaminones |
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