Transition metal-free synthesis of 3-trifluoromethyl chromones via tandem C-H trifluoromethylation and chromone annulation of enaminones

The tandem C-H bond trifluoromethylation and chromone annulation reactions ofo-hydroxyphenyl enaminones have been realized for the practical synthesis of 3-trifluoromethyl chromones. The reactions are performed efficiently with the promotion of K(2)S(2)O(8)without using any transition metal catalyst...

Full description

Saved in:
Bibliographic Details
Published inORGANIC CHEMISTRY FRONTIERS Vol. 7; no. 18; pp. 2770 - 2775
Main Authors Yu, Qing, Liu, Yunyun, Wan, Jie-Ping
Format Journal Article
LanguageEnglish
Published CAMBRIDGE Royal Soc Chemistry 21.09.2020
Royal Society of Chemistry
Subjects
Cascade chemical reactions
Catalysts
Chemical reactions
Chemistry
Chemistry, Organic
Guanidine
Hydrogen bonds
Organic chemistry
Physical Sciences
Potassium persulfate
Pyrimidines
Science & Technology
Substrates
Transition metals
POTENT
ARYLATION
ARENES
BOND FUNCTIONALIZATION
LANGLOIS REAGENT
CARBON-CARBON
AGENTS
FACILE
ACCESS
FLAVONES
Online AccessGet full text

Cover

More Information
Summary:The tandem C-H bond trifluoromethylation and chromone annulation reactions ofo-hydroxyphenyl enaminones have been realized for the practical synthesis of 3-trifluoromethyl chromones. The reactions are performed efficiently with the promotion of K(2)S(2)O(8)without using any transition metal catalyst or additive. In addition, the 3-trifluoromethyl chromone products have been successfully used for the synthesis of 3-trifluoromethyl pyrimidines by reacting with guanidine/amidine substrates.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
ISSN:2052-4129
2052-4110
2052-4110
DOI:10.1039/d0qo00855a