Actl7b deficiency leads to mislocalization of LC8 type dynein light chains and disruption of murine spermatogenesis

• Published in: Development (Cambridge) Vol. 150; no. 21
• Main Authors: Merges, Gina E., Arévalo, Lena, Kovacevic, Andjela, Lohanadan, Keerthika, de Rooij, Dirk G., Simon, Carla, Jokwitz, Melanie, Witke, Walter, Schorle, Hubert
• Format: Journal Article
• Language: English
• Published: 01.11.2023

Actin-related proteins (Arps) are classified according to their similarity to actin and are involved in diverse cellular processes. ACTL7B is a testis-specific Arp, and is highly conserved in rodents and primates. ACTL7B is specifically expressed in round and elongating spermatids during spermiogene...