Cyclometallated ruthenium( ii ) complexes with 3-acetyl-2[ H ]-chromene-2-one derived CNS chelating ligand systems: synthesis, X-ray characterization and biological evaluation

• Published in: New journal of chemistry Vol. 42; no. 1; pp. 336 - 354
• Main Authors: Kalaiarasi, G., Rajkumar, S. Rex Jeya, Dharani, S., Fronczek, Frank R., Muthukumar Nadar, M. S. A., Prabhakaran, R.
• Format: Journal Article
• Language: English
• Published: CAMBRIDGE Royal Soc Chemistry 2018; Royal Society of Chemistry
• Subjects: Albumins; Antioxidants; Bacteria; Biocompatibility; Chelation; Chemistry; Chemistry, Multidisciplinary; Coordination compounds; Coumarin; Crystallography; Deoxyribonucleic acid; DNA; Gram-positive bacteria; Ligands; NMR; Nuclear magnetic resonance; Organoruthenium complexes; Physical Sciences; Pseudomonas aeruginosa; Ruthenium; Ruthenium compounds; Salmonella; Science & Technology; Serum albumin; Single crystals; ANTICANCER ACTIVITY; CARBONYL-COMPLEXES; ANTIPROLIFERATIVE ACTIVITY; DNA CLEAVAGE; HUMAN SERUM-ALBUMIN; BIS(THIOSEMICARBAZONE) COMPLEXES; PROTEIN-BINDING; IN-VITRO CYTOTOXICITY; SCHIFF-BASE COMPLEXES; CELLULAR UPTAKE

Four new bivalent organoruthenium complexes incorporated with 3-acetylcoumarin-4( N )-substituted thiosemicarbazones were synthesized. Comprehensive spectral and analytical techniques such as elemental analyses, IR, UV-vis, 1 H NMR and 13 C NMR provided proof of the formation of the complexes ( 1–4...