Rhodium(i)-catalyzed C-S bond formation via enantioselective carbenoid S-H insertion: catalytic asymmetric synthesis of α-thioesters

• Published in: ORGANIC CHEMISTRY FRONTIERS Vol. 9; no. 13; pp. 3467 - 3472
• Main Authors: Sun, Yu-Tuo, Rao, Xiaofeng, Xu, Weici, Xu, Ming-Hua
• Format: Journal Article
• Language: English
• Published: CAMBRIDGE Royal Soc Chemistry 28.06.2022; Royal Society of Chemistry
• Subjects: Asymmetric synthesis; Asymmetry; Bonding; Catalysis; Chemical synthesis; Chemistry; Chemistry, Organic; Enantiomers; Insertion; Organic chemistry; Physical Sciences; Rhodium; Science & Technology; Sulfur; Thioesters; Transition metals; FDA-APPROVED DRUGS; ALKENES; ACTIVATION; METALLO-BETA-LACTAMASE; CYCLOPROPANATION; THIOMANDELIC ACID; SULFUR; INHIBITOR; ACCESS

Asymmetric construction of C-S bonds through transition-metal catalysis is a challenging subject. By using chiral diene as the ligand, we have developed the first rhodium(i)-catalyzed asymmetric carbene insertion approach for C-S bond formation to access sulfur-substituted stereocenters under mild c...