N-Methyl-D-Aspartate receptor antagonist treatment in traumatic brain injury: a systematic review of the clinical studies

• Published in: Expert review of neurotherapeutics Vol. 25; no. 8; p. 991
• Main Authors: Muradov, Jamil H, Reid, Hannah, Parker, Ellen, Phinney, Jackie, Clarke, David B, Friedman, Alon, MacLean, Mark A
• Format: Journal Article
• Language: English
• Published: England 03.08.2025
• Subjects: Amantadine - therapeutic use; Brain Injuries, Traumatic - drug therapy; Excitatory Amino Acid Antagonists - therapeutic use; Humans; Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors; efficacy of NMDAR antagonist treatment; Traumatic brain injury; brain injury treatment timing; treatment outcomes; adverse effects of NMDAR treatment; NMDAR antagonist; clinical trials of NMDAR antagonists; mechanism-driven treatment

Traumatic brain injury (TBI) is a leading cause of long-term disability. N-methyl-D-aspartate receptor (NMDAR) signaling constitutes an important target for pharmacological treatment options. The authors have systematically reviewed primary clinical literature reporting on FDA-approved NMDAR antagon...