Living related liver transplantation for fulminant hepatitis the role as a hepatologist and pediatrician

We performed living related liver transplantation for fulminant hepatitis (5 men and 2 women, aged 7 months to 33 years) who were evaluated by the selection committee for liver transplantation from 1994 to February 1996. The etiology of the hepatitis was unknown in all patients, and duration from th...

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Published inKanzo Vol. 38; no. 1; pp. 27 - 33
Main Authors HASEGAWA, Kiyoshi, ITOU, Katumi, KOJIMA, Shinnji, HAYASHI, Naoaki, ISHIKAWA, Kayo, SHIRAGA, Kouji, HASHIMOTO, Etsuko, NOGUCHI, Sanshirou
Format Journal Article
LanguageJapanese
Published The Japan Society of Hepatology 1997
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ISSN0451-4203
1881-3593
DOI10.2957/kanzo.38.27

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Abstract We performed living related liver transplantation for fulminant hepatitis (5 men and 2 women, aged 7 months to 33 years) who were evaluated by the selection committee for liver transplantation from 1994 to February 1996. The etiology of the hepatitis was unknown in all patients, and duration from the onset to development of grade II hepatic coma ranged from 7 to 26 days. A request for liver transplantation was made 9 to 35 days after the onset and 0 to 17 days after the development of encephalopathy. The time from a request for liver transplantation until selection committee ranged from 2 to 17 days. Living related liver transplantation was performed in all eligible patients, at 1 to 7 days after the decision of the committee. We realized that living related liver transplantation can be undertaken quickly on demand.
AbstractList We performed living related liver transplantation for fulminant hepatitis (5 men and 2 women, aged 7 months to 33 years) who were evaluated by the selection committee for liver transplantation from 1994 to February 1996. The etiology of the hepatitis was unknown in all patients, and duration from the onset to development of grade II hepatic coma ranged from 7 to 26 days. A request for liver transplantation was made 9 to 35 days after the onset and 0 to 17 days after the development of encephalopathy. The time from a request for liver transplantation until selection committee ranged from 2 to 17 days. Living related liver transplantation was performed in all eligible patients, at 1 to 7 days after the decision of the committee. We realized that living related liver transplantation can be undertaken quickly on demand.
Author ITOU, Katumi
NOGUCHI, Sanshirou
HAYASHI, Naoaki
SHIRAGA, Kouji
ISHIKAWA, Kayo
KOJIMA, Shinnji
HASEGAWA, Kiyoshi
HASHIMOTO, Etsuko
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  organization: Department of Institute of Gastroenterology, Tokyo Women's Medical College
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  fullname: KOJIMA, Shinnji
  organization: Department of Institute of Gastroenterology, Tokyo Women's Medical College
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  fullname: HAYASHI, Naoaki
  organization: Department of Institute of Gastroenterology, Tokyo Women's Medical College
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  fullname: ISHIKAWA, Kayo
  organization: Department of Institute of Gastroenterology, Tokyo Women's Medical College
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  fullname: SHIRAGA, Kouji
  organization: Department of Institute of Pediatric Nephrology, Tokyo Women's Medical College
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  fullname: HASHIMOTO, Etsuko
  organization: Department of Institute of Gastroenterology, Tokyo Women's Medical College
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  fullname: NOGUCHI, Sanshirou
  organization: Department of Institute of Gastroenterology, Tokyo Women's Medical College
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References 3) 武藤泰敏: 劇症肝炎における肝移植の適応. 市田文弘, 谷川久一編, 肝移植適応基準, 東京, 国際医書出版, 1991, p4-12
4) 武藤泰敏, 杉原潤一, 石木佳英, 他: 劇症肝炎における肝移植適応のガイドライン (案). 日本急性肝不全研究会, 1996年3月
6) Heffron TG, Emond JC: Living related donor liver transplantation. In: Transplantation of the Liver. Edited by Maddrey WC, Sorrell MF, Appieton & Lange Press, Connecticut, 1995, p97-106
19) Cattral MS, Langnas AN, Markin RS: Aplastic anemia after liver transplantation for fulminant liver failure. Hepatology 20: 813- 818, 1994
18) Fox IJ, Langnas AN, Fristone LW: Successful application of extracorporeal liver perfusion: A techonolog whose time has come. Am J Gastroenterol 88: 1876-1881, 1993
7) 神代龍吉: 劇症肝炎に対する肝移植の適応. 谷川久一, 野口和典編, 日本における肝移植の将来, 東京, 国際医書出版, 1996, p26-34
14) Nakazato P, Young C, Moritz M: Auxiliary liver transplantation. In: Transplantation of the Liver. Edited by Maddrey WC, Sorrell MF, Appleton & Lange Press, Connecticut, 1995, p106-122
8) Takahashi Y, Kumada H, Shimizu M: A multicenter study on the prognosis of fulminant viral hepatitis: Early prediction for liver transplantation. Hepatology 19: 1065-1071, 1994
15) Boudjema K, Cherqui D, Jaeck D: Auxiliary liver transplantation for fulminant and subfulminant hepatic failure. Transplantation 59: 218-223, 1995
12) Lee WM, Galbraith RM, Watt GH: Predicting survival in fulminant hepatic failure using serum Ge protein concentration. Hepatology 21: 101-105, 1995
16) Chenard-Neu MP, Boudjema K, Bemuau J : Auxiliary liver transplantation: Regeneration of the native liver and outcome in 30 patient with fulminant hepatic failure-A multicenter Europian study. Hepatology 23: 1119-1127, 1996
1) 渕之上昌平: 肝移植におけるインフォームド・コンセントと問題点. MB Gastro 3 (8) : 1-6, 1993
17) Chari RS, Collins BH, Magee JC: Treatment of hepatic failure with in vivo pig-liver perfusion followed by liver transplantation. New Engl J Med 331: 234-237, 1994
20) Collins RH, Klintmalm G: Aplastic anemia after liver transplantation. Hepatology 22: 1011, 1995
11) Hoofnagle JH, Carithers RL, Shapiro C: Fulminant hepatic failure: Summary of a workshop. Hepatology 21: 240-252, 1995
2) O'Grady JG, Alexander GM, Hayllar KM: Early indications of prognosis in fulminant hepatic failure. Gastroenterology 97: 439, 1989
5) 谷川久一, 野口和典編: 日本における肝移植の将来. 東京, 国際医書出版, 1996, p26-34
9) Bernuau J, Goudeau A, Poynard T: Multivariate analysis of prognostic factors in fuiminant hepatitis B. Hepatology 6: 648-651, 1986
13) Isoyama K, Tada J, Ishikawa A: Surgical or medical treatment for fulminant hepatic failure in children. Lancet 343: 859, 1994, Apr 2
10) Williams R, Wedon J: Indications for orthotopic liver transplantation in fulminant liver failure. Hepatology 20 (Suppl 5) : 5S-10S, 1994
References_xml – reference: 7) 神代龍吉: 劇症肝炎に対する肝移植の適応. 谷川久一, 野口和典編, 日本における肝移植の将来, 東京, 国際医書出版, 1996, p26-34
– reference: 5) 谷川久一, 野口和典編: 日本における肝移植の将来. 東京, 国際医書出版, 1996, p26-34
– reference: 15) Boudjema K, Cherqui D, Jaeck D: Auxiliary liver transplantation for fulminant and subfulminant hepatic failure. Transplantation 59: 218-223, 1995
– reference: 1) 渕之上昌平: 肝移植におけるインフォームド・コンセントと問題点. MB Gastro 3 (8) : 1-6, 1993
– reference: 3) 武藤泰敏: 劇症肝炎における肝移植の適応. 市田文弘, 谷川久一編, 肝移植適応基準, 東京, 国際医書出版, 1991, p4-12
– reference: 14) Nakazato P, Young C, Moritz M: Auxiliary liver transplantation. In: Transplantation of the Liver. Edited by Maddrey WC, Sorrell MF, Appleton & Lange Press, Connecticut, 1995, p106-122
– reference: 16) Chenard-Neu MP, Boudjema K, Bemuau J : Auxiliary liver transplantation: Regeneration of the native liver and outcome in 30 patient with fulminant hepatic failure-A multicenter Europian study. Hepatology 23: 1119-1127, 1996
– reference: 19) Cattral MS, Langnas AN, Markin RS: Aplastic anemia after liver transplantation for fulminant liver failure. Hepatology 20: 813- 818, 1994
– reference: 18) Fox IJ, Langnas AN, Fristone LW: Successful application of extracorporeal liver perfusion: A techonolog whose time has come. Am J Gastroenterol 88: 1876-1881, 1993
– reference: 11) Hoofnagle JH, Carithers RL, Shapiro C: Fulminant hepatic failure: Summary of a workshop. Hepatology 21: 240-252, 1995
– reference: 9) Bernuau J, Goudeau A, Poynard T: Multivariate analysis of prognostic factors in fuiminant hepatitis B. Hepatology 6: 648-651, 1986
– reference: 8) Takahashi Y, Kumada H, Shimizu M: A multicenter study on the prognosis of fulminant viral hepatitis: Early prediction for liver transplantation. Hepatology 19: 1065-1071, 1994
– reference: 20) Collins RH, Klintmalm G: Aplastic anemia after liver transplantation. Hepatology 22: 1011, 1995
– reference: 13) Isoyama K, Tada J, Ishikawa A: Surgical or medical treatment for fulminant hepatic failure in children. Lancet 343: 859, 1994, Apr 2
– reference: 6) Heffron TG, Emond JC: Living related donor liver transplantation. In: Transplantation of the Liver. Edited by Maddrey WC, Sorrell MF, Appieton & Lange Press, Connecticut, 1995, p97-106
– reference: 17) Chari RS, Collins BH, Magee JC: Treatment of hepatic failure with in vivo pig-liver perfusion followed by liver transplantation. New Engl J Med 331: 234-237, 1994
– reference: 2) O'Grady JG, Alexander GM, Hayllar KM: Early indications of prognosis in fulminant hepatic failure. Gastroenterology 97: 439, 1989
– reference: 10) Williams R, Wedon J: Indications for orthotopic liver transplantation in fulminant liver failure. Hepatology 20 (Suppl 5) : 5S-10S, 1994
– reference: 12) Lee WM, Galbraith RM, Watt GH: Predicting survival in fulminant hepatic failure using serum Ge protein concentration. Hepatology 21: 101-105, 1995
– reference: 4) 武藤泰敏, 杉原潤一, 石木佳英, 他: 劇症肝炎における肝移植適応のガイドライン (案). 日本急性肝不全研究会, 1996年3月
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Title Living related liver transplantation for fulminant hepatitis the role as a hepatologist and pediatrician
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