Quantification of SHR0302 in human plasma by UPLC–MS/MS and application to a pharmacokinetic study

• Published in: Biomedical chromatography Vol. 36; no. 11; pp. e5474 - n/a
• Main Authors: Ding, Li‐kun, Chen, Yan, Liu, Mei‐you, Gao, Xiao‐hua, Ren, Dan‐jun, Diao, Qing‐bo, Yang, Lin, Wen, Ai‐dong, Wang, Jing‐wen
• Format: Journal Article
• Language: English
• Published: 01.11.2022
• Subjects: pharmacokinetics; plasma; rheumatoid arthritis; SHR0302; UPLC–MS/MS

SHR0302, as a novel Janus kinase (JAK) inhibitor 1, is used for treatment of rheumatoid arthritis (RA) in humans. A novel and sensitive ultra‐high performance liquid chromatography–tandem mass spectrometry (UPLC–MS/MS) has been developed and validated for determining the concentration of SHR0302 in...